Development of a Controlled Released System Based on IPN Types Hydrogel for Cartilage Repair

IF 1 Q3 MULTIDISCIPLINARY SCIENCES

gazi university journal of science Pub Date : 2023-09-08 DOI:10.35378/gujs.1295326

Evrim SEVER, Mehlika PULAT

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引用次数: 0

Abstract

The aim of this study is to develop a controlled Fluconazole and Naproxen releasing system for cartilage repair. A series of interpenetrating polymer network (IPN) type of hydrogels were prepared by using 2-Hydroxyethyl methacrylate (HEMA) and gelatin in different ratios. The hydrogels were synthesized by using ammonium persulfate (APS) and sodium metabisulfite (SBS) as initiator pair and ethylene glycol dimethacrylate (EGDMA) and glutaraldehyde (GA) as cross linkers. The prepared hydrogels were characterized via hydrogel formation and swelling/degradation measurements, Fourier Transform Infrared Spectroscopy (FTIR) and Scanning Electron Microscope (SEM) analysis. From swelling tests, it is observed that semi-IPN hydrogels swell much more than full-IPNs which crosslinked by two agents, EGDMA and GA. The higher ratios of HEMA/gelatin negatively affect swelling values. In general, the IPN hydrogel discs were not affected by the variation of temperature. The release studies of Fluconazole and Naproxen were performed at 37 ⁰C and it is found that the swelling and release profiles were similar to each other. The releases of drugs increase rapidly at first and then complies nearly 36 h-48 h. Because of the looser and porous structure, semi-IPN hydrogels have higher release values than full-IPNs.

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基于IPN型水凝胶的软骨修复控制释放系统的研制

本研究的目的是开发一种用于软骨修复的氟康唑和萘普生控制释放系统。以甲基丙烯酸2-羟乙酯(HEMA)和明胶为原料，以不同的配比制备了一系列互穿聚合物网络型水凝胶。以过硫酸铵(APS)和焦亚硫酸钠(SBS)为引发剂，乙二醇二甲基丙烯酸酯(EGDMA)和戊二醛(GA)为交联剂，合成了水凝胶。通过水凝胶形成和溶胀/降解测试、傅里叶红外光谱(FTIR)和扫描电镜(SEM)分析对制备的水凝胶进行了表征。膨胀试验表明，半ipn水凝胶比由EGDMA和GA交联的全ipn水凝胶膨胀大得多。较高的HEMA/明胶比例对溶胀值有不利影响。总的来说，IPN水凝胶盘不受温度变化的影响。氟康唑和萘普生的释放研究在37⁰C进行，发现肿胀和释放曲线彼此相似。在36 h-48 h左右，药物释放先快速增加，然后趋于稳定。由于半ipn水凝胶的结构更疏松、多孔，其释放值高于全ipn水凝胶。

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来源期刊

gazi university journal of science MULTIDISCIPLINARY SCIENCES-

CiteScore

1.60

自引率

11.10%

发文量

期刊介绍： The scope of the “Gazi University Journal of Science” comprises such as original research on all aspects of basic science, engineering and technology. Original research results, scientific reviews and short communication notes in various fields of science and technology are considered for publication. The publication language of the journal is English. Manuscripts previously published in another journal are not accepted. Manuscripts with a suitable balance of practice and theory are preferred. A review article is expected to give in-depth information and satisfying evaluation of a specific scientific or technologic subject, supported with an extensive list of sources. Short communication notes prepared by researchers who would like to share the first outcomes of their on-going, original research work are welcome.