Hormones common to the neuroendocrine and immune systems.

Drug design and delivery Pub Date : 1989-05-01
D J Carr, D A Weigent, J E Blalock
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Abstract

Considerable progress is now being made in studies of the interactions between the immune and neuroendocrine systems, and the relevance of the results to many disease processes is increasingly recognised. Recent published, and hitherto unpublished, work on one aspect of this topic--the production and function of neuroendocrine hormone by cells of the immune system--is herein summarised by a foremost investigator and his colleagues. Evidence is presented that several peptide hormones (ACTH, endorphins, thyrotropin, chorionic gonadotropin, growth hormone) are produced constitutionally, or in response to stimulation, by cells of the immune system, and there is speculation as to their roles in local immune response, endotoxic shock, antibody production, pregnancy, and in the diagnosis of specific psychiatric and neuroendocrine disorders. The review and commentary contribute to fuller understanding of the underlying molecular biology, from which new opportunities in rational drug design will undoubtedly emerge.

神经内分泌系统和免疫系统共有的激素。
免疫系统和神经内分泌系统之间相互作用的研究正在取得相当大的进展,其结果与许多疾病过程的相关性也日益得到认识。最近发表的和迄今未发表的关于该主题的一个方面的工作-免疫系统细胞的神经内分泌激素的产生和功能-在此由一位重要的研究者和他的同事总结。有证据表明,几种肽激素(促肾上腺皮质激素、内啡肽、促甲状腺激素、绒毛膜促性腺激素、生长激素)是由免疫系统细胞在机体或对刺激的反应中产生的,它们在局部免疫反应、内毒素休克、抗体产生、妊娠以及特定精神和神经内分泌疾病的诊断中起着推测作用。这些综述和评论有助于更全面地理解潜在的分子生物学,由此无疑会出现合理药物设计的新机会。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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