Liquisolid Technique: A Novel Technique with Remarkable Applications in Pharmaceutics

Q3 Pharmacology, Toxicology and Pharmaceutics

Current drug discovery technologies Pub Date : 2023-10-10 DOI:10.2174/0115701638258285230921025512

Sahibpreet Singh, Jyoti Singh Singh, Disha Arora

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引用次数: 0

Abstract

Abstract: Recently, it has been observed that newly developed drugs are lipophilic and have low aqueous solubility issues, which results in a lower dissolution rate and bioavailability of the drugs. To overcome these issues, the liquisolid technique, an innovative and advanced approach, comes into play. This technique involves the conversion of the drug into liquid form by dissolving it in non-volatile solvent and then converting the liquid medication into dry, free-flowing, and compressible form by the addition of carrier and coating material. It offers advantages like low cost of production, easy method of preparation, and compactable with thermo labile and hygroscopic drugs. It has been widely applied for BCS II drugs to enhance dissolution profile. Improving bioavailability, providing sustained release, minimizing pH influence on drug dissolution, and improving drug photostability are some of the other promising applications of this technology. This review article presents an overview of the liquisolid technique and its applications in formulation development.

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液体固体技术:在制药领域具有重要应用的新技术

摘要:近年来，人们发现新开发的药物具有亲脂性和低水溶性问题，这导致药物的溶出率和生物利用度较低。为了克服这些问题，液体固体技术，一种创新和先进的方法，开始发挥作用。该技术包括通过将药物溶解在非挥发性溶剂中将其转化为液体形式，然后通过添加载体和涂层材料将液体药物转化为干燥、自由流动和可压缩的形式。它具有生产成本低，制备方法简单，与热不稳定性和吸湿性药物紧凑等优点。它已被广泛应用于BCS II型药物，以提高溶出谱。提高生物利用度，提供缓释，最小化pH值对药物溶解的影响，以及改善药物的光稳定性是该技术的其他一些有前途的应用。本文综述了液固技术及其在配方开发中的应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current drug discovery technologies Pharmacology, Toxicology and Pharmaceutics-Drug Discovery

CiteScore

3.70

自引率

0.00%

发文量

期刊介绍： Due to the plethora of new approaches being used in modern drug discovery by the pharmaceutical industry, Current Drug Discovery Technologies has been established to provide comprehensive overviews of all the major modern techniques and technologies used in drug design and discovery. The journal is the forum for publishing both original research papers and reviews describing novel approaches and cutting edge technologies used in all stages of drug discovery. The journal addresses the multidimensional challenges of drug discovery science including integration issues of the drug discovery process.