[Resistance to cephalosporin in hospital strains of the KES group].

F Granatiero, C Grandis, M Malandrino, R Oneglio
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Abstract

In our laboratory KES group bacteria account for about 11% of all strains isolated from in-patients and are responsible for serious infections. Their well known increasing tendency to become resistant to beta-lactams prompted us to the KES strains isolated in medical or surgical patients in 1986.87. 30 Klebsiella retrospectively review the susceptibility to antibiotics of strains out of 59 had been isolated in that period from patients previously treated with beta-lactams: no significant variation in resistance to cephalosporins, compared to the 29 strains from non treated patients, was noted. However in the treated group one strain of Klebsiella pneumoniae out of 24 showed resistance to ceftazidime and one of Klebsiella oxytoca was resistant both to cefotaxime (1 out of 16) and ceftriaxone (1 out of 12). 19 strains of Enterobacter spp. out of 32 had bees isolated from treated patients; a significant increase in resistance to 3rd generation cephalosporins (p less than 0.01), compared to the 13 strains isolated from non treated patients, was noted. Our findings suggest that it is advisable to review the in-use antibiotic policy keeping in mind the severity of the infections caused by KES group bacteria.

[KES组医院菌株对头孢菌素的耐药性]。
在我们的实验室中,KES群细菌约占从住院患者中分离出的所有菌株的11%,是导致严重感染的原因。众所周知,它们对β -内酰胺具有越来越强的耐药性,这促使我们注意到1986年在内科或外科病人中分离到的KES菌株。30回顾性回顾了在此期间从先前接受β -内酰胺治疗的患者中分离到的59株克雷伯菌对抗生素的敏感性:与未接受治疗的患者中分离到的29株菌株相比,对头孢菌素的耐药性没有显著变化。在治疗组,24株肺炎克雷伯菌中有1株对头孢他啶耐药,1株对头孢噻肟和12株头孢曲松均耐药。32株肠杆菌中有19株从治疗患者身上分离出蜜蜂;注意到,与从未接受治疗的患者中分离的13株菌株相比,对第三代头孢菌素的耐药性显著增加(p < 0.01)。我们的研究结果提示,应考虑到KES群细菌引起的感染的严重程度,对正在使用的抗生素政策进行审查。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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