Exploring structural brain atypicalities in children with obstetric brachial plexus palsy: a voxel-based morphometry analysis.

Q4 Medicine

Genes and Cells Pub Date : 2023-11-13 DOI:10.23868/gc568311

Dzerassa Kadieva, Federico Gallo, Maxim Ulanov, Anna Shestakova, Victoria Moiseeva, Alina Hodorovskaya, Olga Agranovich

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引用次数: 0

Abstract

Background. Obstetric brachial plexus palsy (OBPP) is an injury-related disease in newborns, usually originating from nerve tearing during a difficult vaginal delivery, leading to paralysis of one of the upper limbs. Even though modern treatment methods can guarantee almost full reinnervation of the limb, some patients still show poor motor function. One of the reason for this discrepancy might be the alternation in the brain resulting from a restricted use of the limb since birth. Aim. The present study thus aimed to compare gray matter volumes between children with OBPP and healthy. Methods. Using a voxel-based morphometry (VBM) technique in SPM12 package (Statistical Parametric Mapping) in MATLAB R2019b, we analyzed forty-six structural MRIs of children with OBPP (n=24, mean age=10.2, 12 female, n females=12) and healthy age-matched controls (n=22, mean age=9.63, n females=10). Results. We found volumetric differences between patients and healthy controls which survived a stringent FWE control over false discovery (all with FWE-corrected p 0.005). The results indicated that children with OBPP had significantly lower volumes of the left Amygdala, Hippocampus and right Entorhinal area. Conclusion. Taking into account previous investigations of these areas, we can speculate that the Amygdala-Hippocampus-Entorhinal Cortex complex might play a significant role in motor-related behavior.

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探讨产科臂丛神经麻痹患儿脑结构的非典型性:基于体素的形态学分析。

背景。产科臂丛神经麻痹(OBPP)是新生儿的一种损伤相关疾病，通常起源于阴道分娩困难时的神经撕裂，导致上肢瘫痪。尽管现代治疗方法可以保证肢体几乎完全的神经再生，但一些患者仍然表现出运动功能差。造成这种差异的原因之一可能是由于自出生以来肢体的使用受到限制而导致大脑的变化。的目标。因此，本研究旨在比较OBPP儿童和健康儿童的灰质体积。方法。使用MATLAB R2019b中SPM12软件包(统计参数映射)中的体素形态测量(VBM)技术，我们分析了46例OBPP儿童(n=24，平均年龄=10.2，女性12，女性n= 12)和健康年龄匹配对照(n=22，平均年龄=9.63，女性n= 10)的结构mri。结果。我们发现在严格的FWE控制中幸存的患者和健康对照者之间的体积差异(所有FWE校正p为0.005)。结果表明，OBPP患儿左侧杏仁核、海马和右侧鼻内区体积明显降低。结论。考虑到之前对这些区域的研究，我们可以推测杏仁核-海马体-内嗅皮层复合体可能在运动相关行为中起着重要作用。

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来源期刊

Genes and Cells Medicine-Transplantation

CiteScore

0.50

自引率

0.00%

发文量

期刊介绍： “Genes and Cells” (the old name is “Cell Transplantology and Tissue Engineering”) is a peer-reviewed scientific and practical journal recommended by the Higher Attestation Commission of the Ministry of Education and Science of the Russian Federation for publishing basic materials of dissertation research. Originally conceived as a highly specialized publication, the Journal has now gained an ever wider target audience. If at the beginning of its journey — from September 2005 — the target audience of the journal were biotechnologists, specialists in the field of molecular and cell biology, by now it has expanded with medical practitioners. Such progressive dynamics are absolutely natural — over the last 7-10 years, biomedical technologies have come out of the exotic category, lack of understanding of the inhabitants and mistrust of clinicians have been replaced by interest and awareness of the need to use biotechnology tools in medicine no longer tomorrow, but today. The sections of the journal are formulated to fully disclose the target topics of the publication, convey to readers the opinions of leading experts in the field of biomedical technologies on topical issues of concern, acquaint them with the most significant recent foreign and domestic research, materials of thematic conferences, present analytical information on fundamental issues of biomedical technologies trends in the biotech business. The journal includes the following headings: “expert opinions”, “cell technology news”, “reviews”, “original research”, “clinical experience”, “discussion and general theoretical work”, “stem cell business”.