Pathogenetic and clinical features of stroke associated with COVID-19

Abstract

The novel coronavirus infection COVID-19 remains at the peak of current medical and social problems around the world. The incidence of the coronavirus infection remains at a fairly high level, despite new methods of diagnosis and treatment. The highest incidence of COVID-19 cases is observed among people with concomitant cardiovascular diseases. Such patients quite often develop COVID-19‑associated complications from various organs and systems, among which acute stroke is the most severe. The pathogenesis of stroke in COVID-19 is multifaceted. The key mechanisms for the development of acute cerebrovascular accidents in severe infections are the disruption of regulatory cortical and vegetative functions, hyperproduction of proinflammatory cytokines, and the disorder in the hemostasis system. This article analyzes current literature data on the features of the pathogenesis of stroke and its clinical course in patients with the novel coronavirus infection.