Side Effects of COVID-19 Vaccination Among Healthcare Workers in Tehran, Iran

IF 0.3 Q4 MEDICINE, LEGAL

International Journal of Medical Toxicology and Forensic Medicine Pub Date : 2023-09-30 DOI:10.32598/ijmtfm.v13i3.40536

Davood Yadegarynia, Shabnam Tehrani, Fahimeh Hadavand, Shahnam Arshi, Zahra Abtahian, Amirreza Keyvanfar, Azar Darvishi, Afshin Zarghi

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引用次数: 0

Abstract

Background: Since the emergence of coronavirus disease 2019 (COVID-19), many people have been vaccinated worldwide. Despite the preventive role of vaccines, their side effects face disease management with challenges. This study aims to investigate the side effects of COVID-19 vaccination among healthcare workers in Tehran, Iran. Methods: This cross-sectional study was conducted from April to October 2022 on 377 healthcare workers in Tehran, Iran. Data collection was carried out through an interview by a researcher using a checklist assessing systemic and local side effects of COVID-19 vaccines. Results: The mean age of participants was 36.03±10.24 years, and 68.2% were female. Participants experienced significantly more local (26.5% vs. 14.3%, P<0.001) and systemic (52.0% vs. 31.8%, P<0.001) side effects after the first dose than after the second dose. After the first dose, AstraZeneca (45.9%) caused significantly more local reactions than Sputnik V (21.7%) and Sinopharm (14.5%). AstraZeneca (83.7%) caused significantly more systemic side effects than Sputnik V (50.7%) and Sinopharm (14.5%). The prevalence of local and systemic side effects after the first dose was significantly different in terms of vaccine types (P<0.001). After the second dose, AstraZeneca (20.4%) caused significantly more local reactions than Sputnik V (12.8%) and Sinopharm (10.5%) (P<0.001). Additionally, AstraZeneca (38.8%) and Sputnik V (37.4%) caused significantly more systemic side effects than Sinopharm (7.9%) (P<0.001). Conclusion: Most healthcare workers in Tehran experienced flu-like symptoms and local reactions at the injection site after vaccination against COVID-19, mainly after the first dose. They had more side effects after vaccination with AstraZeneca and Sputnik V, compared to Sinopharm.

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伊朗德黑兰医护人员接种COVID-19疫苗的副作用

背景:自2019冠状病毒病(COVID-19)出现以来，全世界有许多人接种了疫苗。尽管疫苗具有预防作用，但其副作用使疾病管理面临挑战。本研究旨在调查伊朗德黑兰卫生保健工作者接种COVID-19疫苗的副作用。方法:这项横断面研究于2022年4月至10月对伊朗德黑兰的377名卫生保健工作者进行。数据收集是通过研究人员使用评估COVID-19疫苗全身和局部副作用的清单进行的访谈进行的。结果:参与者平均年龄36.03±10.24岁，女性占68.2%。与第二次给药相比，第一次给药后，参与者经历了更多的局部(26.5% vs. 14.3%， P<0.001)和全身(52.0% vs. 31.8%， P<0.001)副作用。首次给药后，阿斯利康(45.9%)局部反应发生率明显高于Sputnik V(21.7%)和国药(14.5%)。阿斯利康(83.7%)的系统性副作用发生率明显高于Sputnik V(50.7%)和国药(14.5%)。首次注射后局部和全身副作用的发生率在疫苗类型方面存在显著差异(P<0.001)。第二次给药后，阿斯利康(20.4%)的局部反应发生率明显高于Sputnik V(12.8%)和国药(10.5%)(P<0.001)。此外，阿斯利康(38.8%)和Sputnik V(37.4%)的系统性副作用明显高于国药(7.9%)(P<0.001)。结论:德黑兰大多数医护人员在接种COVID-19疫苗后出现流感样症状和局部反应，主要是在第一剂后。与国药相比，他们接种阿斯利康和Sputnik V后的副作用更多。

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