between interleukin-6 and endotoxin an in vitro study

Sawsan Mohsen
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Abstract

Endotoxin, a component of the outer membrane of Gram-negative bacteria, has been extensively studied as a stimulator of the innate immune response. However, the temporal aspects and exposure-response relationship of endotoxin and resulting cytokine induction. This in vitro study aimed to investigate the factors influencing the interleukin-6 (IL-6) response to bacterial endotoxin stimulation. IL-6 is a pro-inflammatory cytokine that plays a crucial role in the immune response and inflammation. In this study, we utilized an in vitro model to examine the factors influencing IL-6 production in response to bacterial endotoxin this experimental study was performed to find out the effect of healthy person on peripheral blood mononuclear cells(PBMCs) namely T-cells and natural killer cells(NK cells) function through challenging their ability for cytokines production in a comparative study by using of standardized inoculum of Bacterial endotoxins.
白细胞介素-6与内毒素的体外研究
内毒素是革兰氏阴性菌外膜的一种成分,作为先天免疫反应的刺激物被广泛研究。然而,内毒素和细胞因子诱导的时间方面和暴露-反应关系。本体外实验旨在探讨影响白细胞介素-6 (IL-6)对细菌内毒素刺激反应的因素。IL-6是一种促炎细胞因子,在免疫反应和炎症中起着至关重要的作用。本研究采用体外模型研究细菌内毒素作用下白细胞介素6 (IL-6)产生的影响因素,采用标准化接种细菌内毒素,通过挑战外周血单核细胞(t细胞)和自然杀伤细胞(NK细胞)产生细胞因子的能力,对比研究健康人对外周血单核细胞(t细胞)和NK细胞功能的影响。
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