The significance of Na+ ions in angiotensin II stimulation of acquisition of active avoidance in rats.

Abstract

Angiotensin II (1 microgram) dissolved in water and given intracerebroventricularly on day 1, 15 min before the first learning session, enhanced rate of learning of active avoidance in rats over the next 7 days. However, the peptide, dissolved in 0.25 M NaCl, and given at the same dose and route, stimulated learning significantly more than that dissolved in water. A possible involvement of Na+ ions in facilitating learning action of A II is discussed.