Effect of calmodulin inhibitors on rat and guinea pig myocardial contractility.

Acta physiologica Polonica Pub Date : 1989-09-01
B I Laptev, V D Prokopieva, S A Afanasiev, N P Larionov
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Abstract

The effects of phenothiazine drugs with different affinities for calmodulin (trifluoperazine, frenolone, majeptile and aminazine) on the contractility of rat and guinea pig papillary muscles were studied. The phenothiazine-induced changes in the contraction-relaxation parameters were shown to correlate with the degree of calmodulin inhibition. These parameters are relaxation-onset index, relaxation index and terminal relaxation index in rats, and relaxation index and maximal developed tension in guinea pigs. An essential role of calmodulin in myocardium relaxation in both animal species is postulated.

钙调素抑制剂对大鼠和豚鼠心肌收缩力的影响。
研究了对钙调素具有不同亲和性的吩噻嗪类药物(三氟拉嗪、氟诺酮、马吉普妥和胺嗪)对大鼠和豚鼠乳头肌收缩力的影响。吩噻嗪引起的收缩松弛参数变化与钙调素抑制程度相关。这些参数分别是大鼠的松弛起始指数、松弛指数和末期松弛指数,以及豚鼠的松弛指数和最大发展张力。钙调素在两种动物的心肌松弛中都起着重要的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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