Rationale for the planned clinical trials with nerve growth factor in Alzheimer's disease.

Psychiatric developments Pub Date : 1989-01-01
F Hefti, L S Schneider
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Abstract

A large number of experimental studies on animals suggest that intraventricular administration of NGF to Alzheimer patients may attenuate the degeneration of cholinergic neurons and the behavioral consequences associated with the cholinergic deficits. Based on these findings clinical trials with NGF seem justified, if potential detrimental effects are ruled out. Once NGF administration is proven effective it will be possible to develop alternative ways of NGF administration.

神经生长因子治疗阿尔茨海默病计划临床试验的基本原理。
大量动物实验研究表明,脑室内给予阿尔茨海默病患者神经生长因子可减轻胆碱能神经元的退化以及与胆碱能缺陷相关的行为后果。基于这些发现,如果排除潜在的有害影响,使用神经生长因子进行临床试验似乎是合理的。一旦证明NGF给药有效,就有可能开发NGF给药的替代方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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