New advances in diagnosis and treatment of nano drug delivery systems across the blood-brain barrier

IF 4.2 3区材料科学 Q2 MATERIALS SCIENCE, COMPOSITES

Nanocomposites Pub Date : 2023-09-20 DOI:10.1080/20550324.2023.2256466

Jinyu Wang, Yaqin Yu, Chongqing Zhang, Junling Song, Ziliang Zheng, Weihong Yan

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Abstract

The blood-brain barrier (BBB) is a multicellular neurovascular unit that serves as a highly impermeable cellular barrier to regulate brain homeostasis, protect the central nervous system, and respond to different physiological and pathological states. Recently, new drugs have been discovered to treat neuropathology. However, because BBB blocks the delivery of drugs to the central nervous system (CNS), it is still difficult to translate the treatment of CNS diseases into clinical results. Therefore, overcoming the BBB and realizing efficient delivery of therapeutic drugs is of great significance for the diagnosis and treatment of various neurological diseases such as Alzheimer’s disease, Parkinson’s disease and glioblastoma. Nano drug delivery system (NDDS) has the characteristics of high biocompatibility, high drug load, improving pharmacokinetic behavior of drugs in vivo, achieving targeted drug delivery, controlled drug release, etc. Therefore, in the field of trans-BBB drug delivery, It has broad application prospect for the diagnosis and treatment of various neurological diseases. This paper reviews the latest research on NDDS crossing BBB at home and abroad, providing new ideas for the diagnosis and treatment of CNS diseases.

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跨血脑屏障纳米给药系统诊断和治疗的新进展

血脑屏障(BBB)是一种多细胞神经血管单元，作为一种高度不渗透的细胞屏障，调节脑内稳态，保护中枢神经系统，并对不同的生理和病理状态作出反应。最近，已经发现了治疗神经病理学的新药。然而，由于血脑屏障阻断了药物向中枢神经系统(CNS)的传递，因此仍难以将CNS疾病的治疗转化为临床结果。因此，克服血脑屏障，实现治疗药物的高效递送，对于阿尔茨海默病、帕金森病、胶质母细胞瘤等多种神经系统疾病的诊断和治疗具有重要意义。纳米给药系统(NDDS)具有生物相容性高、载药量大、改善药物在体内药动学行为、实现靶向给药、控释等特点。因此，在跨血脑屏障给药领域，对各种神经系统疾病的诊断和治疗具有广阔的应用前景。本文综述了国内外NDDS穿越血脑屏障的最新研究进展，为中枢神经系统疾病的诊断和治疗提供新的思路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nanocomposites Multiple-

CiteScore

7.40

自引率

15.20%

发文量

审稿时长

16 weeks