Assessment of mechanical responses between trabecular bones and porous scaffolds under static loading and fluid flow conditions: A finite element approach

IF 1.4 4区工程技术 Q2 ENGINEERING, MULTIDISCIPLINARY

International Journal for Multiscale Computational Engineering Pub Date : 2023-01-01 DOI:10.1615/intjmultcompeng.2023049206

Parthasarathi Samanta, Surajit Kundu, Abhisek Gupta, Masud Rana, Nitesh Mondal, Amit Roy Chowdhury

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引用次数: 0

Abstract

3D Porous scaffold is one of the standard and evocative approaches to creating a favorable biomechanical environment in tissue engineering for tissue regeneration and repair. The architectural design parameters (e.g., pore-shape, size, distribution and interconnectivity; permeability; specific surface area etc.) of the porous model have significant influence on their mechano-biological behavior. Flow dynamics of fluid is a very vital phenomenon in understanding how the blood flows through the porous structure which is the responsibility of the biological behavior of the cell. As permeability and porosity are the essential parameters of scaffolds architecture, in this study, von-Mises stress, deformation, wall shear stress (WSS) and the pressure drop across the model have been investigated. Using computational fluid dynamics, geometrical, static structure and WSS are compared with the natural bone with different porosity to identify which architectural design is close to the bone.

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静载荷和流体流动条件下小梁骨和多孔支架之间力学反应的评估:有限元方法

三维多孔支架是在组织工程中为组织再生和修复创造良好生物力学环境的标准和令人回味的方法之一。建筑设计参数(例如孔隙形状、大小、分布及连通性);渗透率;比表面积等)对多孔模型的力学生物学行为有显著影响。流体的流动动力学是理解血液如何在多孔结构中流动的一个非常重要的现象，多孔结构是细胞生物学行为的责任。由于渗透率和孔隙度是支架结构的重要参数，因此本研究对模型的von-Mises应力、变形、壁面剪切应力(WSS)和压降进行了研究。利用计算流体力学，将几何、静力结构和WSS与不同孔隙率的天然骨进行比较，以确定哪种建筑设计接近骨。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal for Multiscale Computational Engineering 工程技术-工程：综合

CiteScore

3.40

自引率

14.30%

发文量

审稿时长

>12 weeks

期刊介绍： The aim of the journal is to advance the research and practice in diverse areas of Multiscale Computational Science and Engineering. The journal will publish original papers and educational articles of general value to the field that will bridge the gap between modeling, simulation and design of products based on multiscale principles. The scope of the journal includes papers concerned with bridging of physical scales, ranging from the atomic level to full scale products and problems involving multiple physical processes interacting at multiple spatial and temporal scales. The emerging areas of computational nanotechnology and computational biotechnology and computational energy sciences are of particular interest to the journal. The journal is intended to be of interest and use to researchers and practitioners in academic, governmental and industrial communities.