Assessment of mechanical responses between trabecular bones and porous scaffolds under static loading and fluid flow conditions: A finite element approach

Abstract

3D Porous scaffold is one of the standard and evocative approaches to creating a favorable biomechanical environment in tissue engineering for tissue regeneration and repair. The architectural design parameters (e.g., pore-shape, size, distribution and interconnectivity; permeability; specific surface area etc.) of the porous model have significant influence on their mechano-biological behavior. Flow dynamics of fluid is a very vital phenomenon in understanding how the blood flows through the porous structure which is the responsibility of the biological behavior of the cell. As permeability and porosity are the essential parameters of scaffolds architecture, in this study, von-Mises stress, deformation, wall shear stress (WSS) and the pressure drop across the model have been investigated. Using computational fluid dynamics, geometrical, static structure and WSS are compared with the natural bone with different porosity to identify which architectural design is close to the bone.