Characterization of biomaterials with reference to biocompatibility dedicated for patient-specific finger implants

IF 0.8 4区 医学 Q4 BIOPHYSICS
Adam Byrski, Magdalena Kopernik, Łukasz Major, Katarzyna Kasperkiewicz, Marcin Dyner, Juergen M. Lackner, David Lumenta, Roman Major
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引用次数: 0

Abstract

Purpose The research was focused on determining basic mechanical properties, surface and phase structure taking into consideration basic cytotoxicity analysis towards human cells. Methods Biological tests were performed on human C-12302 fibroblasts cells using 3D-printed Ti6Al4V alloy (Ti64), produced by laser-based powder bed fusion (LB-PBF) and Alumina Toughened Zirconia 20 (ATZ20), produced by lithography-based ceramic manufacturing (LCM). Surface modifications included electropolishing, and hydroxyapatite or hydroxyapatite/zinc coating. Structure analysis was carried out using a variety of techniques such as X-Ray diffraction, scanning electron microscopy (SEM), transmission electron microscopy (TEM), and confocal laser scanning microscopy (CLSM), followed by mechanical properties evaluation using nanoindentation testing. Results Samples subjected to surface modifications showed diversity among surface and phase structure and mechanical properties. However, the cytotoxicity towards tested cells was not significantly higher than the control. Though, a trend was noted among the materials analysed, indicating that HAp/Zn coating on Ti64 and ATZ20 resulted in the best biological performance Conclusions Hydroxyapatite coating on Ti64 and ATZ20 resulted in the best biological properties. Tested materials are suitable for in vivo toxicity testing.
生物材料的特征,参考生物相容性,专用于患者特定的手指植入物
目的:在对人体细胞进行基本细胞毒性分析的基础上,研究其基本力学性能、表面和相结构。方法采用激光粉末床熔融(LB-PBF)法制备Ti6Al4V合金(Ti64)和光刻陶瓷制造(LCM)法制备氧化铝增韧氧化锆20 (ATZ20),对人C-12302成纤维细胞进行生物实验。表面改性包括电抛光、羟基磷灰石或羟基磷灰石/锌涂层。使用x射线衍射、扫描电子显微镜(SEM)、透射电子显微镜(TEM)和共聚焦激光扫描显微镜(CLSM)等多种技术进行了结构分析,随后使用纳米压痕测试进行了力学性能评估。结果经表面改性后的样品表面、相结构和力学性能呈现多样性。然而,对被试细胞的细胞毒性并不显著高于对照组。结论羟基磷灰石涂层在Ti64和ATZ20表面具有最佳的生物学性能。被试材料适用于体内毒性试验。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Acta of bioengineering and biomechanics
Acta of bioengineering and biomechanics BIOPHYSICS-ENGINEERING, BIOMEDICAL
CiteScore
2.10
自引率
10.00%
发文量
0
期刊介绍: Acta of Bioengineering and Biomechanics is a platform allowing presentation of investigations results, exchange of ideas and experiences among researchers with technical and medical background. Papers published in Acta of Bioengineering and Biomechanics may cover a wide range of topics in biomechanics, including, but not limited to: Tissue Biomechanics, Orthopedic Biomechanics, Biomaterials, Sport Biomechanics.
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