Different bactericidal abilities of plasma-activated saline with varied reactive species prepared by the combinations of surface plasma-activated air and plasma jet

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-11-13 DOI:10.1088/2058-6272/ad0c1f

Yikang Jia, Tianhui Li, Rui Zhang, Pengyu Zhao, Zifeng Wang, Min Chen, Li Guo, Dingxin Liu

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Abstract

Abstract Plasma-activated water (PAW), as an extended form of cold atmospheric-pressure plasma, greatly expands the application of plasma-based technology. The biological effects of PAW are closely related to the aqueous reactive species, which can be regulated by the activation process. In this study, the surface plasma-activated air (SAA) and the He + O2 plasma jet (Jet) were parallelly combined (the SAA + Jet combination) or sequential combined (the SAA → Jet combination and the Jet → SAA combination) to prepare plasma-activated saline (PAS). The PAS activated by the combinations exhibited stronger bactericidal effects than that activated by the SAA or the Jet alone. The concentrations of H2O2 and NO2− were higher in the PAS activated by the Jet → SAA combination, while ONOO− were close in the three kinds of PAS and 1O2 were highest in the PAS activated by the SAA + Jet combination. The analysis of scavengers also demonstrated that H2O2, 1O2, and ONOO‒ in the PAS activated by the SAA + Jet combination, and 1O2 in the PAS activated by the Jet → SAA combination played critical roles in bactericidal effects. Further, the effective placement time of the three PAS varied and the PAS activated by the Jet → SAA combination could also inactivate 2.6-log10 of the MRSA cells after placement for more than 60 min. The regulation of reactive species in plasma-activated water through different combinations of plasma devices could improve the directional application of plasma-activated water in the biomedical field.

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表面等离子体活化空气与等离子体射流组合制备的不同活性物质的等离子体活性盐水的不同杀菌能力

等离子体活化水(PAW)作为低温常压等离子体的延伸形式，极大地拓展了等离子体技术的应用领域。PAW的生物学效应与水中活性物质密切相关，活性物质可通过活化过程调节。本研究采用表面等离子活化空气(SAA)与He + O2等离子射流(jet)平行组合(SAA + jet组合)或顺序组合(SAA→jet组合和jet→SAA组合)制备等离子活化生理盐水(PAS)。组合激活的PAS比单独激活SAA或Jet的杀菌效果更强。Jet→SAA复合激活的PAS中H2O2和NO2−浓度较高，而三种PAS中ONOO−浓度接近，且SAA + Jet复合激活的PAS中1O2浓度最高。清除剂分析还表明，SAA + Jet组合激活的PAS中的H2O2、1O2和ONOO -以及Jet→SAA组合激活的PAS中的1O2在杀菌效果中起关键作用。此外，三种PAS的有效放置时间不同，经Jet→SAA组合激活的PAS在放置60 min以上也能灭活2.6-log10的MRSA细胞。通过不同的等离子体装置组合调节等离子体活化水中的活性物质，可以提高等离子体活化水在生物医学领域的定向应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.