Chemical Synthesis of Substituted Naphthalene Derivatives: A Review

IF 2.2 4区化学 Q2 CHEMISTRY, ORGANIC

Synthesis-Stuttgart Pub Date : 2023-09-20 DOI:10.1055/a-2179-1338

Mittali Maheswari, Nazar Hussain

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Abstract

This review article outlines the progress made in the synthesis of substituted naphthalene derivatives. Naphthalene and its derivatives exhibit various biological activities such as anti-inflammatory, anticancer, antiviral, antitubercular, antimicrobial, antihypertensive, antidiabetic, etc. Several strategies have been developed in the past for the construction of naphthalene derivatives, primarily focused on Metal-catalyzed reactions (palladium, copper, zinc, rhodium, platinum, nickel, etc.,) and Lewis acid-catalyzed transformations. This review discusses the preparations of naphthalene derivatives using various salt such as gallium chlorides, gold chlorides, gold bromides, various gold complexes as well as bronsted acids like triflic acid and trifluoroacetic acid, and Lewis acids such as like boron trifluoride etherate. Additionally, miscellaneous reactions involving metal and Lewis acids are explored. The transformational approaches covered in this review include cycloadditions, carboannulations, benzoannulations, electroannulations, rearrangements, and cross-dehydrogenative coupling reactions. Overall this review provides a comprehensive and up-to-date account of the current state of preparations of substituted naphthalenes, highlighting their medicinal and industrial importance.

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取代萘衍生物的化学合成研究进展

本文综述了取代萘衍生物的合成研究进展。萘及其衍生物具有抗炎、抗癌、抗病毒、抗结核、抗菌、降压、降糖等多种生物活性。过去已经开发了几种策略来构建萘衍生物，主要集中在金属催化反应(钯、铜、锌、铑、铂、镍等)和刘易斯酸催化转化。本文综述了以氯化镓、氯化金、溴化金等各种盐、各种金配合物以及三氟乙酸、三氟乙酸等bronsted酸和三氟化硼等Lewis酸为原料制备萘衍生物的研究进展。此外，还探讨了涉及金属和路易斯酸的各种反应。这篇综述涵盖的转化方法包括环加成、碳环、苯环、电环、重排和交叉脱氢偶联反应。总的来说，这篇综述提供了一个全面和最新的取代萘制剂的现状，突出其药用和工业重要性。

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来源期刊

Synthesis-Stuttgart 化学-有机化学

CiteScore

4.50

自引率

7.70%

发文量

435

审稿时长

1 months

期刊介绍： SYNTHESIS is an international full-paper journal devoted to the advancement of the science of chemical synthesis. It covers all fields of organic chemistry involving synthesis, including catalysis, organometallic, medicinal, biological, and photochemistry, but also related disciplines. SYNTHESIS provides dependable research results with detailed and reliable experimental procedures and full characterization of all important new products as well as scientific primary data.