Efficacy of Beta-Secretase-1 Enzyme Inhibitors in Alzheimer's Disease

Roohallah Yousefi, Shahla Mokarmian, Ali Jamshidi
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Abstract

Background and Objectives: A number of BACE1 inhibitors have been tested in clinical trials but have been discontinued due to lack of efficacy or unacceptable side effects. In this study, we investigate the physicochemical properties of some of these ligands and their binding affinity for the molecular model of the BACE1 enzyme [PDB ID:
β -分泌酶-1酶抑制剂治疗阿尔茨海默病的疗效
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