Permeation Study of Vitamin E Emulgels Using Carrageenan a Marine Biota Products as Gelling Agents

Abstract

Carrageenan as one of marine biota products is widely used in various industries such as food, cosmetics, pharmaceuticals, printing, and textile. Application and use of carrageenan in the manufacture of gels and other gel products is still very limited especially for cosmeceutical products. Caraageenan has the ability to form gels in a thermo-reversible waymaking it widely used as a gelling agent, thickener, stabilizer and additional permeation enhancement. Thereby this study aims to conduct how permeation study of Vitamin E an anti-oxidant in emulgels preparations using Carrageenan as gelling agents compare to another gelling agents (HPMC). In vitro permeation tests by Franz Diffusion Cell showed better result for emulgels Carrageenan than HPMC. The cumulative penetrated amounts of Vitamin E emulgels with Carrageenan was 5262.64±49.37 µg/cm2 while HPMC 4453.90±49.37, Fluks values for emulgels Carrageenan and HPMC was 29.24±0.27 and 24.75±0.27 respectively.