Phytohormone synthesis for PDH activation and phytochemical screening for the treatment of endometriosis

Abstract

Introduction and Aim: Endometriosis is a challenging gynecological disorder that causes pelvic pain and infertility attributed to the prevalence of ectopic endometrial tissue outside the uterine tract. Endometrial tissue can travel to other areas of the body for inexplicable reasons. There are, nevertheless, certain patterns. Endometriosis could be treated in several ways, based on characteristics such as age, fertility, symptom severity, and disease degree. All endometriosis medications are available as contraceptives, restricting their use to pregnant mothers or intending to get children. By comparing human peritoneal mesothelial cells (HPMCs) derived from the pelvic peritoneum of women with endometriosis to HPMCs from women without endometriosis, the researchers found that HPMCs from women with endometriosis had reduced glycolysis, mitochondrial respiration, and pyruvate dehydrogenase (PDH) and improved lactate production. There is no treatment for endometriosis, even though various medications and management alternatives are available. The present study was carried out to find novel medications to treat endometriosis from medicinal plants which appear to be a promising endeavor. Methods and Materials: Phytohormone and phytochemical screening were performed to study the medication options that could possibly treat endometriosis. Phytochemicals were determined using GC-MS. Results: The phytohormone activity and phytochemical components of Mentha piperita, Curcuma longa, and Andrographis paniculata were identified using GC MS and FT-IR analysis. This initial data from the analytical methods will make it easier to perform follow-up research on finding bioactive ingredients, determining their efficacy through in vivo tests, and proving their safety and efficacy through clinical trials to treat endometriosis. Conclusion: Gibberellin, a phytohormone obtained from natural sources, is supposed to improve PDH activity and hence inhibit PDK. The demand for more modern medicines to increase survival in such cases remains unmet. As a result, there is an increasing interest in using herbal therapy to treat endometriosis.