Preparation and Evaluation of Transdermal Patches of an Anti-inflammatory Drug

Abstract

Objective: The objective of the present study was to compare the release effect of Etodolac from different polymeric (hydrophilic and lipophilic) patches prepared by varying concentrations. The best polymeric combination was selected based on the release of the drug from the patches. Methods: Polymers such as HPMC, MC, EC, PVA, Eudragit L-100, and Glycerin was used as a plasticizer. Permeation Enhancers used is Dimethyl Sulfoxide. Transdermal patches were prepared by using the solvent casting technique. FTIR was studied to estimate the incompatibility. Patches were evaluated for physicochemical Characteristics like thickness, weight variation, folding endurance, moisture loss, moisture absorption, water vapor transition, drug content, and In-vitro diffusion studies. Results: The results obtained showed no physical-chemical incompatibility between the drug and the polymers. MC: EC was found to be a suitable polymer compared to other prepared polymeric combinations in the preparation of transdermal patches. From the evaluation of patches F6 containing (1:3) % of MC: EC was considered the best formulation for the transdermal delivery of Etodolac. Conclusion: Transdermal patches were successfully prepared for Etodolac and their evaluation studies of each dosage form revealed that topically applied Etodolac patches possess immense potential to control the release rate of medicament to improve the bioavailability as well as patient compliance.