Screening of two Achillea (Asteraceae) species from Turkey, Achillea coarctata Poir. and Achillea setacea Waldst. & Kit. for volatiles and fatty acids compositions, and antimicrobial activity

IF 0.5 Q4 MULTIDISCIPLINARY SCIENCES

Trakya University Journal of Natural Sciences Pub Date : 2023-10-15 DOI:10.23902/trkjnat.1322140

Gamze GÖGER, Esma ÇEVİK, Alişan VARNALI, Ömer Koray YAYLACI, Medine Münevver UMA, Gülmira ÖZEK

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Abstract

The main aim of this study is antimicrobial screening of the n-hexane, ethyl acetate and aqueous extracts obtained from aerial parts of Achillea setacea Waldst. & Kit. and Achillea coarctata Poir. against the bacterial strains Escherichia coli ATCC 8739, Staphylococcus aureus ATCC 14028 and the yeast Candida albicans ATCC 6633 by the microdilution method. In addition, the effect of the aqueous extract of A. coarctata combined with fluconazole againts C. albicans ATCC 6633, C. parapsilosis ATCC 22019, C. tropicalis ATCC 750 and C. glabrata ATCC 90030 was tested with the checkerboard method. The chemical components of the volatiles and fatty acid methyl esters were identified using the Gas Chromatography (GC) and Gas Chromatography/Mass Spectrometry (GC/MS) techniques. The main components of the volatile oil were found to be 1,8-cineole (16.1%) and β-pinene (14.5%) for A. setacea and camphor (35.4%) and borneol (12.9%) for A. coarctata. The ethyl acetate extracts of A. setacea (MIC=156.25 µg/mL) and A. coarctata (MIC=312.5 µg/mL) were found more active against the tested Candida Berkh. species. The combination of aqueous extract of A. coarctata with fluconazole showed additive effect for the tested Candida species with FIC values within the range of 0.53-0.625 µg/mL.

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土耳其菊科两种菊苣的筛选。和水仙。,装备。用于挥发物和脂肪酸组合物，以及抗菌活性

本研究的主要目的是对水蛭地面部位的正己烷、乙酸乙酯和水提物进行抑菌筛选。, amp;装备。和阿喀琉斯。采用微量稀释法对大肠杆菌ATCC 8739、金黄色葡萄球菌ATCC 14028和白色念珠菌ATCC 6633进行抑菌试验。此外，采用棋盘格法检测荆芥水提液联合氟康唑对白色念珠菌ATCC 6633、副枯枝念珠菌ATCC 22019、热带念珠菌ATCC 750和光秃念珠菌ATCC 90030的抑菌效果。采用气相色谱(GC)和气相色谱/质谱(GC/MS)技术鉴定挥发物和脂肪酸甲酯的化学成分。结果表明，仙丹挥发油的主要成分为1,8-桉叶油脑(16.1%)、β-蒎烯(14.5%)、樟脑(35.4%)和冰片(12.9%)。setacea (MIC=156.25µg/mL)和coarctata (MIC=312.5µg/mL)的乙酸乙酯提取物对Berkh念珠菌的抑制作用较强。物种。水提液与氟康唑复配对所测念珠菌有加性作用，其FIC值在0.53 ~ 0.625µg/mL范围内。

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Trakya University Journal of Natural Sciences MULTIDISCIPLINARY SCIENCES-

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