Outcomes comparison between nsaid and placebo in the occurrence of heterotopic ossification after hip surgery: a systematic review

Abstract

Introduction: Heterotropic Ossification (HO) is a devastating condition felt by patients and surgeons. It was caused by inflammatory response triggered by injury through various processes. NSAID is thought to have a capability to limit the process, hence preventing the condition. Materials and Methods: Various database has been used to search for literatures included in this review. Screening and evaluation were conducted for researches. Results: Seven studies are included in this review and a table has been formed to show the comparison of HO and Control. Discussion : This study aimed to assess the occurrence of heterotopic ossification (HO) after hip arthroscopy and compare outcomes between those who received prophylactic nonsteroidal anti-inflammatory drugs (NSAIDs) and those who did not. The hypothesis was that NSAIDs could reduce postoperative HO. The significance of this trend varied in retrospective research due to differences in NSAID regimens. The usefulness of NSAID prophylaxis should be carefully weighed against potential side effects, and patient compliance should be assessed in future research, as it was inconsistently reported in the existing literature. Conclusion: NSAID lower the rate of postoperative HO, however, more studies need to be conducted to analyze certain efficacy of certain type of HO