Clinical and prognostic value of leptin resistance in the hospital period of myocardial infarction

IF 0.2 Q4 MEDICINE, GENERAL & INTERNAL
E. E. Gorbatovskaya, Ya. A. Dyleva, E. V. Belik, E. G. Uchasova, R. S. Tarasov, V. V. Kashtalap, O. V. Gruzdeva
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Abstract

Aim. To evaluate the prevalence of leptin resistance (LR) and its clinical and prognostic value in association with metabolic disorders and features of the proinflammatory state in the hospital period of myocardial infarction. Materials and methods. The study included 114 men diagnosed with ST segment elevation myocardial infarction (MI). On day 1 and 12 of MI, the levels of leptin and leptin receptor were measured in patients, and the free leptin index (FLI) was calculated. Leptin resistance (LR) was recorded at leptin > 6.45 ng / ml and FLI > 25. A comparative analysis of clinical and anamnestic characteristics, biochemical parameters, and cardiovascular prognosis was carried out between patients with and without LR. Statistical data processing was carried out using the Statistica 10.0 software package and SPSS 17.0 for Windows . Results. The prevalence of LR in the hospital period of MI was 64%. LR was associated with cardiovascular pathology in the family history, arterial hypertension, dyslipidemia, and obesity. The presence of LR was accompanied by a significant increase in the level of glucose, free fatty acids (FFA), and interleukin (IL)-6 on day 1 of MI and by a significant rise in insulin, C-peptide, tumor necrosis factor (TNF)-alpha, and plasminogen activator inhibitor-1 (PAI-1) throughout the hospital stay. Patients with LR were characterized by multi-vessel and more severe lesions of the coronary bed and were more often subject to early post-infarction angina, recurrent MI, rhythm and conduction disturbances during hospital stay for MI. Conclusion. Patients with MI are characterized by high prevalence of LR during the hospital stay. LR is associated with cardiovascular risk factors, metabolic disorders, formation of insulin resistance, and increased proinflammatory and prothrombogenic factors. The identified features in the presence of LR probably contribute to the development of adverse cardiovascular events in the hospital period of MI.
心肌梗死住院期瘦素抵抗的临床及预后价值
的目标。探讨瘦素抵抗(LR)的流行程度及其与心肌梗死住院期代谢紊乱和促炎状态特征的相关性及其临床和预后价值。材料和方法。该研究包括114名诊断为ST段抬高型心肌梗死(MI)的男性。在心肌梗死第1天和第12天,测定患者体内瘦素和瘦素受体水平,并计算游离瘦素指数(FLI)。瘦素抵抗(LR)记录于Leptin >6.45 ng / ml和FLI >25. 比较分析LR患者和非LR患者的临床和记忆特征、生化参数和心血管预后。统计数据处理采用Statistica 10.0软件包和SPSS 17.0 for Windows软件。结果。心肌梗死住院期间LR的发生率为64%。LR与家族史中的心血管病理、动脉高血压、血脂异常和肥胖有关。LR的存在伴随着心肌梗死第1天葡萄糖、游离脂肪酸(FFA)和白细胞介素(IL)-6水平的显著升高,以及整个住院期间胰岛素、c肽、肿瘤坏死因子(TNF)- α和纤溶酶原激活物抑制剂-1 (PAI-1)水平的显著升高。LR患者的特点是冠状动脉床多血管病变,且更严重,更容易发生梗死后早期心绞痛、心肌梗死复发、心肌梗死住院期间心律和传导障碍。心肌梗死患者的特点是住院期间LR的高发率。LR与心血管危险因素、代谢紊乱、胰岛素抵抗的形成以及促炎和促血栓因子的增加有关。在心肌梗死住院期间,LR存在的识别特征可能有助于不良心血管事件的发展。
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来源期刊
Byulleten Sibirskoy Meditsiny
Byulleten Sibirskoy Meditsiny MEDICINE, GENERAL & INTERNAL-
CiteScore
0.70
自引率
50.00%
发文量
102
审稿时长
8 weeks
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