The Activity of Some Antibiotics Depend on Stereochemistry of Them (Its Structure)

Abstract

The chiral carbon in biological compounds lead to its activity, for example, the beta lactam ring contains two carbon centers carbon number three and carbon number four both are chiral carbon. This chirality plays important role in the activity and bind with structures activity relationship. Also the ofloxacin act on topoisomerase which required for protein Synthesis of microorganism, the ofloxacin when become Levo isomer not only racemic mixture the activity is more than the racemic or Dextro isomer. Also, the old Antibiotics Chloramphenicol the RR’ isomers only active not the other isomers of Chloramphenicol.