Effects of COX 1-2 Inhibitors on Prevention of Rocuronium Injection Pain: Controlled, Randomised, Double Blind Study

Mehmet ŞAHAP, Handan GÜLEÇ, Esra ÖZAYAR, Özlem ÖZDEMİR, Merve KACAN, Aysun KURTAY, Eyüp HORASANLI, Abdulkadir BUT
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 Material and Methods: Sixty patients of either sex scheduled for under general anesthesia were enrolled in this study. Patients were allocated into two groups (Group 1: Dexkethoprofen group, Group 2: Control group). Pain was evaluated by during rocuronium injection, patients were scored by a scale showed below. 0; No movement response to injection, 1; Mild movement response to injection, 2; Hand withdrawal response to injection, 3; Arm withdrawal response to injection. We also evaluated the pain with 2 questions when the patient was in the recovery room. Question 1. What was the last feeling before you fall into sleep? and question 2. Did you feel any pain on your hand during medication injection for anesthesia?
 Results: There were differences between the groups in terms of total pain score for example in group 1 there were 16 (53%) patients who did not make any movement during rocuronium injection while there were 22 (73%) patients in group 2.There was significant difference in injection rocuronium bromide pain between group 1: dexkethoprofen group, Group 2: control group in terms of the answer to the second question. Patients felt less pain than the control group. In the second question, 16% in group 2 stated that they felt pain, while this rate was observed as 3% in group 1.
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Abstract

Aim: Rocuronium bromide is a painful agent during induction of general anaesthesia. The aim of the study is to investigate the effects of Cyclooxygenase (COX) inhibitors as a resque agent against the rocuronium pain. Material and Methods: Sixty patients of either sex scheduled for under general anesthesia were enrolled in this study. Patients were allocated into two groups (Group 1: Dexkethoprofen group, Group 2: Control group). Pain was evaluated by during rocuronium injection, patients were scored by a scale showed below. 0; No movement response to injection, 1; Mild movement response to injection, 2; Hand withdrawal response to injection, 3; Arm withdrawal response to injection. We also evaluated the pain with 2 questions when the patient was in the recovery room. Question 1. What was the last feeling before you fall into sleep? and question 2. Did you feel any pain on your hand during medication injection for anesthesia? Results: There were differences between the groups in terms of total pain score for example in group 1 there were 16 (53%) patients who did not make any movement during rocuronium injection while there were 22 (73%) patients in group 2.There was significant difference in injection rocuronium bromide pain between group 1: dexkethoprofen group, Group 2: control group in terms of the answer to the second question. Patients felt less pain than the control group. In the second question, 16% in group 2 stated that they felt pain, while this rate was observed as 3% in group 1. Conclusion: The effect of cox inhibitors on rocuronium pain was seen in our study but control group is also effective in reducing pain in vascular width.
COX 1-2抑制剂对预防罗库溴铵注射疼痛的作用:对照、随机、双盲研究
目的:罗库溴铵是一种全麻诱导痛药。本研究的目的是探讨环氧化酶(COX)抑制剂对罗库溴铵疼痛的缓解作用。材料与方法:本研究纳入60例全麻患者,男女不限。将患者分为两组(1组:右酮洛芬组,2组:对照组)。罗库溴铵注射期间疼痛评估,患者评分如下表所示。0;注射无运动反应,1;注射轻度运动反应,2分;手对注射的撤回反应,3;手臂对注射的反应。当病人在恢复室时,我们也用2个问题来评估疼痛。问题1。入睡前的最后一种感觉是什么?问题2。注射麻醉药物时,您的手感到疼痛吗? 结果:两组患者在总疼痛评分上存在差异,1组16例(53%)患者在注射罗库溴铵过程中没有任何活动,2组22例(73%)患者在注射罗库溴铵过程中没有任何活动。在第2个问题的回答上,组1:右酮洛芬组和组2:对照组注射罗库溴铵疼痛有显著性差异。患者感到的疼痛比对照组少。在第二个问题中,第二组中有16%的人表示他们感到疼痛,而在第一组中这一比例为3%。 结论:本研究发现cox抑制剂对罗库溴铵疼痛有一定的缓解作用,但对照组对血管宽度疼痛也有一定的缓解作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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