Evaluation of Homocysteine, Trace Element, and Vitamin Levels in Male Individuals with Hemorrhoidal Disease

Middle Black Sea Journal of Health Science Pub Date : 2023-10-29 DOI:10.19127/mbsjohs.1351713

Gürkan ÇIKIM, Solmaz SUSAM, Mustafa GÖKSU, Fatih ÜÇKARDEŞ, Muhittin ÖNDERCİ

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Abstract

Objectives: Hemorrhoidal disease is a common and uncomfortable condition affecting people worldwide, primarily in the lower rectal region. This study explores the relationship between hemorrhoidal disease and the levels of homocysteine, folic acid, vitamin B12, zinc, and copper in men. Methods: A prospective study included 38 male patients with internal hemorrhoids (Group I) and 38 healthy male individuals (Group II). Venous blood samples were collected after a 12-hour fast and analyzed for homocysteine, folic acid, vitamin B12, zinc, and copper levels. Statistical analyses, including the Kolmogorov-Smirnov test, Mann-Whitney U or Two-Sample t-test, Receiver Operating Characteristic (ROC) analysis, and Multivariate Binary Logistic regression, were performed. Results: Group I and Group II had similar age and body mass index (BMI). Homocysteine and copper levels were significantly higher in Group I, while folic acid and vitamin B12 levels were significantly lower. High homocysteine levels (≥11.2 µmol/L) had a sensitivity of 92.11%, while low vitamin B12 (

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评价男性痔疮患者的同型半胱氨酸、微量元素和维生素水平

目的:痔疮病是一种常见病和不适的条件影响世界各地的人，主要是在直肠下区域。本研究探讨了男性同型半胱氨酸、叶酸、维生素B12、锌和铜水平与痔疮疾病之间的关系。方法:对38例男性内痔患者(I组)和38例健康男性(II组)进行前瞻性研究，禁食12小时后采集静脉血，分析同型半胱氨酸、叶酸、维生素B12、锌和铜的水平。统计分析包括Kolmogorov-Smirnov检验、Mann-Whitney U或双样本t检验、受试者工作特征(ROC)分析和多元二元Logistic回归。结果:ⅰ组与ⅱ组年龄相近，体重指数(BMI)相近。第一组的同型半胱氨酸和铜水平显著高于对照组，而叶酸和维生素B12水平显著低于对照组。高同型半胱氨酸水平(≥11.2µmol/L)的敏感性为92.11%，而低维生素B12水平(

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Middle Black Sea Journal of Health Science

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