Creation of bioengineered lung using induced lung progenitor cells

Abstract

In organ engineering, by combining stem cells, biomaterials and bioreactors, it may be possible for scientists to produce bioengineered organs for transplantation, as well as advancing understanding of organs and diseases. Researchers from the Department of Thoracic Surgery at Tohoku University in Japan and the University of Toronto in Canada are conducting multidisciplinary international research led by thoracic surgeon Assistant Professor Takaya Suzuki (Tohoku University) to create a bioengineering lung using induced lung progenitor cells. The research revolves around designing the respiratory system and involves utilising progenitor-generating cellular reprogramming using transient gene transfection. Ultimately, the researchers are seeking to identify a way to intentionally control the developmental clock of the human body and Suzuki believes that this will be possible if the team can unveil the key mechanisms that govern this clock. Suzuki is working closely with Professor Thomas K Waddell at the University of Toronto and Toronto General Hospital. It was in Waddell's lab that the concept of partial reprogramming was conceived, alongside global leading stem cell scientist Professor Andras Nagy. Alongside his collaborators, Suzuki is seeking to transform the landscape of transplantation medicine. As partial reprogramming can be employed in various organs and cells, any kind of organ bioengineering can benefit from the research.