Current Considerations in the Diagnosis and Treatment of Circadian Rhythm Sleep-Wake Disorders in Children

IF 2.4 4区医学 Q2 CLINICAL NEUROLOGY

Seminars in Pediatric Neurology Pub Date : 2023-12-01 DOI:10.1016/j.spen.2023.101091

Rochelle M. Witt , Kelly C. Byars , Kristina Decker , Thomas J. Dye , Jessica M. Riley , Danielle Simmons , David F. Smith

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引用次数: 1

Abstract

Circadian Rhythm Sleep-Wake Disorders (CRSWDs) are important sleep disorders whose unifying feature is a mismatch between the preferred or required times for sleep and wakefulness and the endogenous circadian drives for these. Their etiology, presentation, and treatment can be different in pediatric patients as compared to adults. Evaluation of these disorders must be performed while viewed through the lens of a patient's comorbid conditions. Newer methods of assessment promise to provide greater diagnostic clarity and critical insights into how circadian physiology affects overall health and disease states. Effective clinical management of CRSWDs is multimodal, requiring an integrated approach across disciplines. Therapeutic success depends upon appropriately timed nonpharmacologic and pharmacologic interventions. A better understanding of the genetic predispositions for and causes of CRSWDs has led to novel clinical opportunities for diagnosis and improved therapeutics.

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诊断和治疗儿童昼夜节律睡眠-觉醒障碍的当前考虑因素

昼夜节律睡眠-觉醒障碍（CRSWDs）是一种重要的睡眠障碍，其共同特点是睡眠和觉醒的首选或所需时间与内源性昼夜节律驱动力不匹配。与成人相比，儿童患者的病因、表现和治疗方法可能有所不同。在对这些疾病进行评估时，必须同时考虑患者的合并症。较新的评估方法有望提供更清晰的诊断，并对昼夜节律生理如何影响整体健康和疾病状态提供重要见解。昼夜节律失调症的有效临床管理是多模式的，需要跨学科的综合方法。治疗的成功取决于适时的非药物和药物干预。对 CRSWD 遗传倾向和病因的深入了解为诊断和改进治疗带来了新的临床机遇。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Seminars in Pediatric Neurology CLINICAL NEUROLOGY-PEDIATRICS

CiteScore

4.80

自引率

0.00%

发文量

审稿时长

84 days

期刊介绍： Seminars in Pediatric Neurology is a topical journal that focuses on subjects of current importance in the field of pediatric neurology. The journal is devoted to making the status of such topics and the results of new investigations readily available to the practicing physician. Seminars in Pediatric Neurology is of special interest to pediatric neurologists, pediatric neuropathologists, behavioral pediatricians, and neurologists who treat all ages.