The impact of COVID-19 and other factors on the usage status of the biologic drug therapies for rheumatoid arthritis: A study from Vietnam

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Hai-Binh Bui , Hong-Thinh Lai , Thanh-Lam Nguyen , Thuy-Duong Vu , Nhat-Le Bui , Van-Hung Nguyen , Thi-To-Chau Tran , Thi-Phuong-Thuy Nguyen , Thi-Ngoc-Lan Nguyen , Jaffar A. Al-Tawfiq , Dinh-Toi Chu
{"title":"The impact of COVID-19 and other factors on the usage status of the biologic drug therapies for rheumatoid arthritis: A study from Vietnam","authors":"Hai-Binh Bui ,&nbsp;Hong-Thinh Lai ,&nbsp;Thanh-Lam Nguyen ,&nbsp;Thuy-Duong Vu ,&nbsp;Nhat-Le Bui ,&nbsp;Van-Hung Nguyen ,&nbsp;Thi-To-Chau Tran ,&nbsp;Thi-Phuong-Thuy Nguyen ,&nbsp;Thi-Ngoc-Lan Nguyen ,&nbsp;Jaffar A. Al-Tawfiq ,&nbsp;Dinh-Toi Chu","doi":"10.1016/j.reuma.2023.09.012","DOIUrl":null,"url":null,"abstract":"<div><h3>Objectives</h3><p>To describe the status of using biological Disease Modifying Anti Rheumatic Drugs (bDMARDs) to treat rheumatoid arthritis (RA) and related factors. In addition, the study determined the impact of COVID-19 on the usage of bDMARDs.</p></div><div><h3>Methods</h3><p>This is a cross-sectional study and included 219 RA patients over 18 years old. The Kaplan–Meier method and the log-rank test (<em>p</em> <!-->&lt;<!--> <!-->0.05) were used to estimate the retention time and compare between different times. Cox regression analysis was used to determine the factors affecting the retention time of biological drugs (<em>p</em> <!-->&lt;<!--> <!-->0.05).</p></div><div><h3>Results</h3><p>Out of 1967 courses of treatment, there were 149 (7.6%) drug discontinuations, 760 (38.6%) doses extensions and 64 (3.3%) drug switch. Moderate disease level and choosing tumor necrosis factor (TNF) inhibitors initially were associated with retention time of COVID-19. Drug discontinuations and dose extensions increased after COVID-19 emergence. The retention time during COVID-19 was significantly different from that of pre-COVID-19. Gender, type of first-used bDMARD, conventional synthetic DMARDs (csDMARDs) and corticoid usage status, disease activity levels were associated with retention time.</p></div><div><h3>Conclusion</h3><p>The presence of COVID-19 has a significant effect on usage status of the biologic drug. Further longitudinal studies are needed to clarify the relationship between COVID-19 and drug usage as well as related factors.</p></div>","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":null,"pages":null},"PeriodicalIF":16.4000,"publicationDate":"2023-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Accounts of Chemical Research","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1699258X23002061","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0

Abstract

Objectives

To describe the status of using biological Disease Modifying Anti Rheumatic Drugs (bDMARDs) to treat rheumatoid arthritis (RA) and related factors. In addition, the study determined the impact of COVID-19 on the usage of bDMARDs.

Methods

This is a cross-sectional study and included 219 RA patients over 18 years old. The Kaplan–Meier method and the log-rank test (p < 0.05) were used to estimate the retention time and compare between different times. Cox regression analysis was used to determine the factors affecting the retention time of biological drugs (p < 0.05).

Results

Out of 1967 courses of treatment, there were 149 (7.6%) drug discontinuations, 760 (38.6%) doses extensions and 64 (3.3%) drug switch. Moderate disease level and choosing tumor necrosis factor (TNF) inhibitors initially were associated with retention time of COVID-19. Drug discontinuations and dose extensions increased after COVID-19 emergence. The retention time during COVID-19 was significantly different from that of pre-COVID-19. Gender, type of first-used bDMARD, conventional synthetic DMARDs (csDMARDs) and corticoid usage status, disease activity levels were associated with retention time.

Conclusion

The presence of COVID-19 has a significant effect on usage status of the biologic drug. Further longitudinal studies are needed to clarify the relationship between COVID-19 and drug usage as well as related factors.

COVID-19 和其他因素对类风湿性关节炎生物药物疗法使用状况的影响:越南的一项研究
目的描述使用生物改良抗风湿药(bDMARDs)治疗类风湿性关节炎(RA)的现状及相关因素。此外,该研究还确定了 COVID-19 对使用 bDMARDs 的影响。方法这是一项横断面研究,纳入了 219 名 18 岁以上的 RA 患者。采用卡普兰-梅耶法和对数秩检验(p <0.05)估算保留时间,并在不同时间之间进行比较。结果 在1967个疗程中,有149人(7.6%)停药,760人(38.6%)延长剂量,64人(3.3%)换药。中度疾病水平和最初选择肿瘤坏死因子(TNF)抑制剂与COVID-19的保留时间有关。COVID-19 出现后,停药和延长剂量的情况有所增加。COVID-19 期间的保留时间与 COVID-19 之前的保留时间有显著差异。性别、首次使用的 bDMARDs、传统合成 DMARDs(csDMARDs)的类型以及皮质激素的使用状况、疾病活动水平与留药时间有关。需要进一步开展纵向研究,以明确 COVID-19 与药物使用及相关因素之间的关系。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信