O079 Investigating Hypersomnolence Disorders in South Australia: A Retrospective Audit of Multiple Sleep Latency tests

M O'Reilly, S Mukherjee, C Chai Coetzer, J Mercer, S Ullah, G Naik, P Catcheside, A Walker
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Abstract

Abstract Introduction This study aims to evaluate the characteristics of patients with Narcolepsy Type 1 (NT1), Narcolepsy Type 2 (NT2), and Idiopathic Hypersomnolence (IH) along with diagnostic outcomes in patients referred for a multiple sleep latency test (MSLT) at an Australian hospital. Methods A retrospective audit was performed of all patients who completed an MSLT between January 2018 to January 2023. Results 431 participants (62.4% female; mean±SD age 40.2±16.4 years; BMI 28.6±7.4 kg/m²) who completed MSLTs were included. 95 participants (22%) had a positive MSLT of ≤ 8 minutes, of which 87% (n=83) had a prior night total sleep time on polysomnography of > 6 hours. Gender, age, and BMI did not vary significantly between participants with a mean sleep latency (MSL) ≤ 8 versus >8 minutes (p=0.9, p>0.9, p=0.1 0, respectively). Participants with an MSL ≤ 8 minutes had higher Epworth Sleepiness Scale scores 14.6 ± 5.1 vs 12.5 ± 5.0 (p < 0.001), with more sleep onset REM periods (SOMREPs) 0.82 ± 1.35 vs 0.14 ± 0.49 compared to those with MSL >8 minutes. Further data collection is in progress, but to date, diagnoses were available for 34 participants with MSL ≤ 8 minutes (6 NT1, 8 NT2, 8 IH, 12 Other [i.e., shiftwork disorder, sleep restriction, medication-induced]). Discussion This study seeks to estimate diagnostic frequency and characteristics of patients presenting for evaluation of hypersomnolence. The prevalence of MSL < 8 minutes (22.0%) is consistent with prior studies1,2. Analysis of diagnostic outcomes is pending further data collection in progress.
在南澳大利亚调查嗜睡障碍:多次睡眠潜伏期测试的回顾性审计
摘要:本研究旨在评估1型嗜睡症(NT1)、2型嗜睡症(NT2)和特发性嗜睡症(IH)患者的特征,以及在澳大利亚一家医院进行多次睡眠潜伏期试验(MSLT)的患者的诊断结果。方法对2018年1月至2023年1月期间完成MSLT的所有患者进行回顾性审计。结果431人,其中女性62.4%;平均±SD年龄40.2±16.4岁;BMI(28.6±7.4 kg/m²)完成MSLTs的患者纳入。95名参与者(22%)的MSLT阳性≤8分钟,其中87% (n=83)的多导睡眠图显示,他们之前的总睡眠时间为>6小时。性别、年龄和BMI在平均睡眠潜伏期(MSL)≤8和>8分钟的参与者之间没有显著差异(p=0.9, >0.9, p=0.1)。睡眠时间≤8分钟的受试者Epworth嗜睡量表得分更高(14.6±5.1 vs 12.5±5.0)。0.001),与睡眠时间为8分钟的患者相比,睡眠开始期(somrep)(0.82±1.35 vs 0.14±0.49)更长。进一步的数据收集正在进行中,但迄今为止,34名MSL≤8分钟的参与者(6名NT1, 8名NT2, 8名IH, 12名其他[即轮班障碍,睡眠限制,药物引起的])可诊断。本研究旨在评估嗜睡患者的诊断频率和特征。MSL的患病率<8分钟(22.0%)与先前研究一致1,2。诊断结果的分析有待进一步的数据收集。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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