A Case Report and Review of Literature: Epithelioid Hemangioendothelioma—An Uncommon Challenging Case

IF 0.3 Q4 ONCOLOGY

Indian Journal of Medical and Paediatric Oncology Pub Date : 2023-09-22 DOI:10.1055/s-0043-1774775

Sweta Soni, Bharti Devnani, Poonam Elhence, Kapil Soni, Deepak Vedant, Palak Gupta, Puneet Pareek, Rakesh Kumar Vyas

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Abstract

Abstract Introduction Epithelioid hemangioendothelioma (EHE) is a rare vascular tumor of soft tissue and bone that may uncommonly occur in the liver, lung, and head and neck region. EHEs have a higher predilection for recurrence at the local site as well as distant metastasis. Surgical excision is important and is the treatment in localized diseases. A decision to give adjuvant radiotherapy should be subjective and may differ on case-to-case basis. Limited studies are available exploring the role of targeted or systemic therapy. Case Presentation A 56-year-old lady represented with right-sided submandibular region EHE with bilateral lung metastasis. The patient underwent surgery and radiotherapy followed by targeted therapy tab pazopanib for systemic control. At 2 years of follow-up, positron emission tomography-computed tomography showed local regional control and stable systemic diseases. Conclusion The uncertainty in choosing the most suitable treatment of EHE patients is high and may result in dissatisfactory outcomes among several patients. The present case study identified a treatment dilemma making management more challenging for rare EHE with mandibular involvement.

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上皮样血管内皮瘤:罕见且具挑战性的病例报告及文献复习

上皮样血管内皮瘤(EHE)是一种罕见的软组织和骨骼血管性肿瘤，通常发生在肝脏、肺部和头颈部。EHEs有较高的局部复发和远处转移的倾向。手术切除是治疗局限性疾病的重要方法。给予辅助放疗的决定应该是主观的，并可能因病例而异。有限的研究可用于探索靶向或全身治疗的作用。病例表现:56岁女性，右侧下颌骨下EHE伴双侧肺转移。患者接受手术和放疗，随后接受帕唑帕尼靶向治疗以进行全身控制。随访2年，正电子发射断层扫描-计算机断层扫描显示局部区域控制和稳定的全身性疾病。结论EHE患者在选择最合适的治疗方法时存在较大的不确定性，可能导致个别患者的治疗效果不满意。本病例研究确定了一个治疗困境，使管理更具有挑战性的罕见EHE下颌骨累及。

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来源期刊

Indian Journal of Medical and Paediatric Oncology ONCOLOGY-

CiteScore

0.40

自引率

0.00%

发文量

期刊介绍： The journal will cover technical and clinical studies related to medical and pediatric oncology in human well being including ethical and social issues. Articles with clinical interest and implications will be given preference.