Alternative Splicing Changes in Human Aging Brain Samples

Abstract

Alternative splicing affects differential isoform generation from genes and may also affect the protein products cellular function. Targeted splicing analysis of exon array analysis of young compared to middle and old post mortem brain samples from 1,234 samples (a total of 10 brain regions) aged from 16 to over 100 allowed me to detect significant alternative splicing changes upon human aging. This kind of data may allow us to better understand the underlying molecular mechanisms.