{"title":"In vitro effect of a glycopeptide acting in vivo on hepatocyte cell cycle.","authors":"M N Lombard, C Nadal, M J Monnot","doi":"10.1111/j.1365-2184.1987.tb01358.x","DOIUrl":null,"url":null,"abstract":"<p><p>A factor specifically inhibiting the hepatocyte cell cycle in vivo was found to block the G1-S transition of liver cells in vitro. It proved to be non-toxic in our culture conditions, as judged by the reversibility of the effect on cell proliferation. It was not active on DNA synthesis in fibroblastic cell lines (3T3).</p>","PeriodicalId":75682,"journal":{"name":"Cell and tissue kinetics","volume":"20 5","pages":"493-7"},"PeriodicalIF":0.0000,"publicationDate":"1987-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1365-2184.1987.tb01358.x","citationCount":"3","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cell and tissue kinetics","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1111/j.1365-2184.1987.tb01358.x","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 3
Abstract
A factor specifically inhibiting the hepatocyte cell cycle in vivo was found to block the G1-S transition of liver cells in vitro. It proved to be non-toxic in our culture conditions, as judged by the reversibility of the effect on cell proliferation. It was not active on DNA synthesis in fibroblastic cell lines (3T3).
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