WHO, what, when, where, and why: New classification systems for acute myeloid leukemia and their impact on clinical practice

IF 2.2 4区 医学 Q3 HEMATOLOGY
Frederick R. Appelbaum
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引用次数: 0

Abstract

The goal of a disease classification system is (or should be) to provide a tool for researchers and clinicians to study and treat the disease. The last decade has seen a markedly improved understanding of the pathophysiology of acute myeloid leukemia (AML), the development of new methods to measure the disease, and approval by the Food and Drug Administration (FDA) of at least ten new therapies targeted to its treatment. In response, in 2022 one updated and one new AML classification system were published. In the same year, the European LeukemiaNet updated their recommendations about how to incorporate the advances in diagnosis and treatment into the risk stratification of AML and its treatment. The following discussion summarizes the highlights of these changes and offers an opinion of how well these changes meet the goal of aiding researchers and clinicians in the study and treatment of AML.

WHO, What, When, Where, and Why:急性髓性白血病的新分类系统及其对临床实践的影响
疾病分类系统的目标是(或应该是)为研究人员和临床医生提供研究和治疗疾病的工具。在过去的十年中,人们对急性髓性白血病(AML)的病理生理学有了显著的了解,新的疾病测量方法得到了发展,美国食品和药物管理局(FDA)批准了至少十种针对其治疗的新疗法。作为回应,2022年发布了一个更新的和一个新的“反洗钱”分类系统。同年,欧洲白血病网络更新了关于如何将诊断和治疗方面的进展纳入AML及其治疗的风险分层的建议。下面的讨论总结了这些变化的亮点,并提出了这些变化在多大程度上满足了帮助研究人员和临床医生研究和治疗AML的目标。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
4.20
自引率
0.00%
发文量
42
审稿时长
35 days
期刊介绍: Best Practice & Research Clinical Haematology publishes review articles integrating the results from the latest original research articles into practical, evidence-based review articles. These articles seek to address the key clinical issues of diagnosis, treatment and patient management. Each issue follows a problem-orientated approach which focuses on the key questions to be addressed, clearly defining what is known and not known, covering the spectrum of clinical and laboratory haematological practice and research. Although most reviews are invited, the Editor welcomes suggestions from potential authors.
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