Malacoplakia of the urinary bladder: case report and systematic review

Oleksandr Boiko, Giselle Mutsinzi Mukarukaka, Miren Imaz-Murga, Eva Domínguez, Mykola Boiko, Andrea Carlevaris-Fernández, Antonio Arruza-Echevarría
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Abstract

Introduction: Malacoplakia is a rare chronic inflammatory disease that commonly affects the urinary bladder, and it is characterized by the presence of large cells containing vacuoles known as Michaelis-Gutmann bodies. Case report: A 79-year-old woman was admitted to the emergency department a poorly defined with symptoms of fever, dysuria, hematuria, and pain and swelling in her right knee. Microbiological studies indicated the presence of Escherichia coli in blood cultures, urine cultures, and synovial fluid cultures of the right knee. A computed tomography scan revealed nonspecific bladder thickening, which was further confirmed by a cystoscopy. A poorly defined lesion in the trigone was resected, and subsequent pathological examination revealed the presence of malacoplakia without evidence of malignancy. The patient was treated with antibiotic therapy, and the hematuria eventually resolved. Systematic review: We conducted a comprehensive search in the Medline, EMBASE, and WoS databases from January 1, 1993, to January 1, 2023, for articles that focused on Malacoplakia, involved human subjects. Were included 32 articles reporting on 35 cases of urinary bladder malacoplakia. The majority of those diagnosed with bladder malacoplakia were women under the age of 50, with recurrent urinary tract infections and immunosuppressive conditions as frequent comorbidities. Positive cultures showed Escherichia coli (E. coli) in 72% of cases. Successful outcomes were achieved in 26 cases (74.3%). Discussion: Malacoplakia is triggered by an inadequate immune system response to lower urinary tract infections. Diagnosis requires prior biopsies before resection or more aggressive treatments. Appropriate treatment of urinary tract infections with antibiotics targeted at gram-negative bacteria is essential for treating malacoplakia.
膀胱斑疹:病例报告及系统回顾
简介:黄斑病是一种罕见的慢性炎症性疾病,通常影响膀胱,其特征是存在含有空泡的大细胞,称为Michaelis-Gutmann小体。病例报告:一名79岁女性因发热、排尿困难、血尿、右膝疼痛和肿胀等不明确的症状被急诊科收治。微生物学研究表明在右膝的血液培养、尿液培养和滑液培养中存在大肠杆菌。计算机断层扫描显示非特异性膀胱增厚,膀胱镜检查进一步证实。在三角区一个不明确的病变被切除,随后的病理检查显示斑疹的存在,没有恶性肿瘤的证据。患者经抗生素治疗,血尿最终消失。系统评价:我们从1993年1月1日至2023年1月1日在Medline、EMBASE和WoS数据库中进行了全面检索,检索了涉及人类受试者的关于斑疹病的文章。纳入35例膀胱斑疹的32篇文章。大多数被诊断为膀胱斑疹的患者是50岁以下的女性,经常伴有尿路感染和免疫抑制疾病。阳性培养显示大肠杆菌(E. coli)占72%。成功26例(74.3%)。讨论:斑疹是由免疫系统对下尿路感染反应不足引起的。诊断需要在切除或更积极的治疗前进行活检。适当使用针对革兰氏阴性菌的抗生素治疗尿路感染对治疗黄斑病至关重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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