The Effects of Acute Bouts of Aerobic Exercise on Adipokine Concentrations in Individuals with Moderate Stages of Chronic Kidney Disease

Tomas J. Chapman-Lopez, James Kyle Taylor, Ricardo Torres, Dylan Wilburn, LesLee K. Funderburk, Dale C. Allison, Jeffrey S. Forsse
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引用次数: 1

Abstract

This study examined the effects of two different acute bouts of treadmill running (e.g., steady-state moderate-intensity exercise (SSE) and high-intensity interval exercise (HIIE)) on adipokine (e.g., adiponectin, leptin, and omentin) concentrations in individuals with moderate stages of chronic kidney disease (CKD). Fourteen participants (8 females and 6 males) (age 58.7 ± 9.7, height (cm) 168.5 ± 9.7, weight (kg) 83.5 ± 18.2) were classified as having moderate stages of CKD (stages G3a and G3b; estimated glomerular filtration rate (eGFR) between 59 and 30 mL/min/1.73 m2). Participants completed 30 min of either SSE at 65% oxygen consumption reserve (VO2R) or HIIE for 3 min at a 90% VO2R separated by 2 min of slow walking (20% VO2R) in a randomized, crossover design on a treadmill. Venous blood samples were obtained at baseline, 1 h, and 24 h post exercise. Data were analyzed using a two by three repeated measures ANOVA (p < 0.05). There were no significant differences in adiponectin (p < 0.353), leptin (p < 0.084), and omentin (p < 0.235) concentrations between SSE and HIIE. Similarly, no significant differences were seen between the sampled time points for either aerobic exercise condition. In conclusion, this study demonstrated there were no changes in adiponectin, leptin, or omentin concentrations when performing an acute bout of HIIE or SSE for 30 min, at 1 or 24 h post exercise. Future studies should seek to either increase the duration of the exercise bout or identify different adipokines to examine for patients experiencing moderate stages of CKD.
急性有氧运动对中度慢性肾病患者脂肪因子浓度的影响
本研究检测了两种不同的急性跑步机运动(例如,稳态中等强度运动(SSE)和高强度间歇运动(HIIE))对中度慢性肾脏疾病(CKD)患者脂肪因子(例如,脂联素、瘦素和网膜)浓度的影响。14名参与者(8名女性,6名男性)(年龄58.7±9.7,身高(cm) 168.5±9.7,体重(kg) 83.5±18.2)被划分为中度CKD (G3a和G3b期;估计肾小球滤过率(eGFR)在59至30 mL/min/1.73 m2之间)。在随机交叉设计中,参与者在跑步机上以65%耗氧量(VO2R)完成30分钟的SSE或以90%耗氧量(VO2R)完成3分钟的HIIE,其中2分钟慢走(20% VO2R)。在运动后基线、1小时和24小时采集静脉血样本。数据分析采用二乘三重复测量方差分析(p <0.05)。两组间脂联素含量差异无统计学意义(p <0.353),瘦素(p <0.084),网膜(p <SSE与HIIE之间的浓度差异为0.235)。同样,两种有氧运动条件下的采样时间点之间也没有显著差异。总之,本研究表明,在运动后1或24小时进行30分钟的HIIE或SSE急性发作时,脂联素、瘦素或网膜蛋白浓度没有变化。未来的研究应该寻求增加运动回合的持续时间或确定不同的脂肪因子来检查中度CKD患者。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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