Possible role of features of the intestinal microbiome in patients with colorectal cancer as a cause of anastomotic leak

IF 0.2 Q4 MEDICINE, GENERAL & INTERNAL
P. V. Kosareva, R. A. Konev, A. P. Godovalov, L. V. Sivakova, E. I. Samodelkin
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Abstract

Aim. Following the analysis of literature data, to determine significant factors of intestinal obstruction in patients with colorectal cancer. Materials and methods. We analyzed 84 literature sources from the Scopus, Web of Science, Google Scholar, and PubMed databases, as well as open access articles on Google. Results. The predominant causes of anastomotic leaks after operations for colorectal cancer are discussed, the role of the microbiome in the development of postoperative complications is analyzed. The intestinal microbiome of patients with colorectal cancer contains bacteria that are not normally found under physiological conditions. These bacteria contribute to the development of disease, suture failure after surgery for intestinal obstruction, and progression of carcinogenesis. This effect is due to the production of bacterial metabolites, the effect on the human immunity, and competition with obligate intestinal microflora. On the other hand, the use of drug therapy, including antibiotics, leads to mass death of obligate bacteria. Therefore, it is important to search for drugs and treatment methods that, if possible, do not have a significant negative impact on the microbiome, but are capable of destroying pathogenic microorganisms. The concept of Russian authors was proposed, which consists in the intraluminal use of rifaximin-α for the prevention of purulent and septic complications and anastomotic leaks during reconstructive surgeries on the distal colon.
结肠直肠癌患者肠道微生物群特征作为吻合口瘘原因的可能作用
的目标。通过对文献资料的分析,确定结直肠癌患者肠梗阻的显著因素。材料和方法。我们分析了来自Scopus、Web of Science、Google Scholar和PubMed数据库的84篇文献来源,以及Google上的开放获取文章。结果。探讨结直肠癌术后吻合口瘘的主要原因,分析微生物群在术后并发症发生中的作用。结直肠癌患者的肠道微生物群中含有生理条件下通常不存在的细菌。这些细菌有助于疾病的发展,肠梗阻手术后缝合失败和癌变的进展。这种影响是由于细菌代谢产物的产生,对人体免疫的影响,以及与专性肠道微生物群的竞争。另一方面,使用药物治疗,包括抗生素,导致专性细菌的大量死亡。因此,重要的是寻找药物和治疗方法,如果可能的话,不会对微生物群产生显著的负面影响,但能够破坏致病微生物。俄罗斯作者提出的概念是,在远端结肠重建手术中,在腔内使用利福昔明-α来预防化脓性和脓毒性并发症和吻合口泄漏。
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来源期刊
Byulleten Sibirskoy Meditsiny
Byulleten Sibirskoy Meditsiny MEDICINE, GENERAL & INTERNAL-
CiteScore
0.70
自引率
50.00%
发文量
102
审稿时长
8 weeks
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