Renal Doppler sonography as a non-invasive technique for early detection of reno-vascular changes in sickle cell disease in children

IF 0.5 Q4 PEDIATRICS
Mona Hassan Eltagui, Hadeel M. Seif Eldein, Marwa Abd Elhady, Dalia El-Sayed, Nouran Momen, Yasmeen M. M. Selim, Mai Mohammed Abd EL Salam
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引用次数: 0

Abstract

Abstract Objective Early identification of sickle renovascular changes via renal Doppler sonography among sickle cell disease patients to help in early diagnosis and interventions to prevent progression to end-stage renal disease. Methods Forty-five SCD children were included along with 45 healthy control children. Renal Doppler sonography (PI and RI) was performed on all subjects. Laboratory investigations were done: Hb electrophoresis, complete blood picture with blood indices, reticulocyte count, liver enzymes (ALT and AST), HCV serology, serum ferritin, and lactate dehydrogenase (LDH). Urine analysis and albumin/creatinine ratio in urine were done for all patients as well. Results The study group consisted of 45 SCD patients, 27 (60%) males with a mean age of 12 years (± 3 years). By performing renal Doppler sonography, it was found that all study groups had significantly higher Doppler indices (resistivity index and pulsatility index) compared to the control group. Results of renal Doppler sonography revealed that the main renal pulsatility index was positively correlated with the main renal resistance index ( r = 0.454, p = 0.002). Conclusion Doppler indices (resistance index and pulsatility index) were of value to assess reno-vascular changes in SCD, Thus, renal Doppler indices could be an early technique in the assessment of sickle renovascular changes, so treatment can be started at an early stage before progressive affection of renal function.
肾多普勒超声作为无创技术早期检测儿童镰状细胞病肾血管改变
目的通过肾多普勒超声早期识别镰状细胞病患者的镰状肾血管改变,有助于早期诊断和干预,防止进展为终末期肾脏疾病。方法选取45例SCD患儿和45例健康对照。所有受试者均行肾多普勒超声检查(PI和RI)。实验室检查:Hb电泳,全血图与血液指标,网织红细胞计数,肝酶(ALT和AST), HCV血清学,血清铁蛋白,乳酸脱氢酶(LDH)。对所有患者进行尿液分析和尿液白蛋白/肌酐比值。结果研究组SCD患者45例,男性27例(60%),平均年龄12岁(±3岁)。通过肾脏多普勒超声检查发现,各研究组的多普勒指数(电阻率指数和脉搏指数)均明显高于对照组。肾多普勒超声结果显示,主肾搏动指数与主肾阻力指数呈正相关(r = 0.454, p = 0.002)。结论肾多普勒指标(阻力指数和脉搏指数)可作为评价SCD肾血管变化的早期指标,可在肾脏功能受到进展性影响前尽早开始治疗。
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来源期刊
自引率
0.00%
发文量
32
审稿时长
9 weeks
期刊介绍: The Gazette is the official journal of the Egyptian Pediatric Association. The main purpose of the Gazette is to provide a place for the publication of high-quality papers documenting recent advances and new developments in both pediatrics and pediatric surgery in clinical and experimental settings. An equally important purpose of the Gazette is to publish local and regional issues related to children and child care. The Gazette welcomes original papers, review articles, case reports and short communications as well as short technical reports. Papers submitted to the Gazette are peer-reviewed by a large review board. The Gazette also offers CME quizzes, credits for which can be claimed from either the EPA website or the EPA headquarters. Fields of interest: all aspects of pediatrics, pediatric surgery, child health and child care. The Gazette complies with the Uniform Requirements for Manuscripts submitted to biomedical journals as recommended by the International Committee of Medical Journal Editors (ICMJE).
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