POTENTIAL AMELIORATIVE EFFECT OF PROPOLIS AGAINST THE DEVELOPMENTAL TOXICITY INDUCED BY OXALIPLATIN IN ALBINO RATS PRIOR AND DURING PREGNANCY

Abstract

, the groups 2, 3, and 4 received PRO (200 mg/kg body weight, orally/daily), OXA (3 mg/kg body weight, intravenous injection, three times/week), OXA+PRO, respectively, for 21 days pre-pregnancy; while, the groups 5, 6, and 7 received the same treatments and doses for 21 days during pregnancy. The results of the current study showed that – as compared to the OXA-induced renal and splenic toxicity in maternal rats and their neonates – co-administration of PRO with OXA either prior or during pregnancy conferred a crucial protective role to overwhelm the OXA-induced histopathological alterations in the renal and spleen tissues.