Early improvement of nailfold videocapillaroscopy abnormalities in dermatomyositis patients with anti-NXP-2 antibody

Abstract

This study aimed to evaluate long-term changes in nailfold videocapillaroscopy (NVC) findings in dermatomyositis patients with antinuclear matrix protein 2 (NXP-2) antibody (Ab). All four patients with anti-NXP-2 Ab presented irregularly enlarged and reduced capillaries and hemorrhages at the initial assessment. After disease stabilization, irregularly enlarged capillaries and hemorrhages disappeared within the mean observation period of 6 months. These early improvements were not observed in patients with anti-TIF1 Ab. The results of this study show that long-term changes in NVC findings should be assessed using myositis-specific Ab information.