The effects of Portulaca oleracea extract on 24-hour urine indices in patients with renal stone: A double-blind randomized placebo-controlled clinical trial

IF 0.2 Q4 UROLOGY & NEPHROLOGY

Journal of Renal Injury Prevention Pub Date : 2023-10-02 DOI:10.34172/jrip.2023.32240

Amirhesam Alirezaei, Kimia Karimi Toudeshki, Seyed Behnaz Nouri, Seyed Amirhossein Fazeli, Firoze Hatami, Amirhossein Miladipour, Seyed Pedram Montazeri-Ghominezhad

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Abstract

Introduction: Portulaca oleracea, or purslane, is a medicinal plant used in traditional medicine, according to its various medical properties, as well as its potential antioxidant and anti-inflammatory properties. Objectives: The present study aimed to investigate the efficacy of P. oleracea powder on 24-hour urine indices in patients with nephrolithiasis and normal kidney function. Patients and Methods: In this randomized clinical trial, eligible patients with nephrolithiasis were randomly assigned to receive P. oleracea or placebo capsules once daily for eight weeks. Twenty-four-hour urine indices, along with serum electrolytes, inflammatory and lipid components were measured, then compared between the two groups at baseline and the end of the trial. Results: A total of 54 patients, including 28 in P. oleracea and 26 in the control groups, were assigned. Their mean age was 42.2±9.8 years; there was no statistically significant difference between the mean age of the P. oleracea and placebo groups (42.1years versus 42.2 years, respectively; P>0.05). After eight weeks, the mean urine citrate level in the Portulaca oleracea subjects (674.82±94.56 mg/24 h) was significantly higher than placebo group subjects (579.19±85.06 mg/24 h; P<0.01). In addition, the mean urine calcium level in the P. oleracea group (176.32±27.40 mg/24 h) was significantly lower compared to the control group (194.26±25.17 mg/24 h; P=0.016). Within the groups, analysis revealed that in subjects in P. oleracea and control groups, mean serum triglyceride (TG) decreased after intervention (P=0.01 and P=0.02, respectively), as well as mean urine citrate level (P<0.01, P=0.01, respectively). Conclusion: The findings show that P. oleracea may be proposed as a medicinal plant that has a preventive effect on kidney stone formation by increasing urine citrate and decreasing urine calcium level. Trial Registration: The trial protocol was approved by the Iranian Registry of Clinical Trials (identifier: IRCT20170725035305N4; https://en.irct.ir/trial/42388, ethical code; IR.SBMU.MSP. REC.1398.538).

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马齿苋提取物对肾结石患者24小时尿指标的影响:一项双盲随机安慰剂对照临床试验

马齿苋，或马齿苋，是一种药用植物，用于传统医学，根据其各种医学特性，以及其潜在的抗氧化和抗炎特性。目的:观察马花苋散对肾功能正常的肾结石患者24小时尿指标的影响。患者和方法:在这项随机临床试验中，符合条件的肾结石患者被随机分配接受马齿苋或安慰剂胶囊，每天一次，持续8周。测量24小时尿液指数、血清电解质、炎症和脂质成分，然后比较两组在基线和试验结束时的差异。结果:共纳入54例患者，其中马齿苋组28例，对照组26例。平均年龄42.2±9.8岁;马齿苋组和安慰剂组的平均年龄无统计学差异(分别为42.1岁和42.2岁);P> 0.05)。8周后，马齿苋组尿中柠檬酸盐的平均水平(674.82±94.56 mg/24 h)显著高于安慰剂组(579.19±85.06 mg/24 h);术中,0.01)。此外，马齿苋组平均尿钙水平(176.32±27.40 mg/24 h)显著低于对照组(194.26±25.17 mg/24 h);P = 0.016)。在组内分析发现，马齿苋组和对照组受试者干预后平均血清甘油三酯(TG)下降(P=0.01和P=0.02)，平均尿柠檬酸水平下降(P<0.01, P=0.01)。结论:马齿苋可能是一种通过提高尿柠檬酸盐和降低尿钙水平来预防肾结石形成的药用植物。试验注册:试验方案已获得伊朗临床试验注册中心批准(标识符:IRCT20170725035305N4;https://en.irct.ir/trial/42388，道德准则;IR.SBMU.MSP。REC.1398.538)。

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来源期刊

Journal of Renal Injury Prevention UROLOGY & NEPHROLOGY-

CiteScore

1.60

自引率

0.00%

发文量

期刊介绍： The Journal of Renal Injury Prevention (JRIP) is a quarterly peer-reviewed international journal devoted to the promotion of early diagnosis and prevention of renal diseases. It publishes in March, June, September and December of each year. It has pursued this aim through publishing editorials, original research articles, reviews, mini-reviews, commentaries, letters to the editor, hypothesis, case reports, epidemiology and prevention, news and views and renal biopsy teaching point. In this journal, particular emphasis is given to research, both experimental and clinical, aimed at protection/prevention of renal failure and modalities in the treatment of diabetic nephropathy. A further aim of this journal is to emphasize and strengthen the link between renal pathologists/nephropathologists and nephrologists. In addition, JRIP welcomes basic biomedical as well as pharmaceutical scientific research applied to clinical nephrology. Futuristic conceptual hypothesis that integrate various fields of acute kidney injury and renal tubular cell protection are encouraged to be submitted.