Genetic predictors of Peyronie’s disease: review

Abstract

Peyronie’s disease (PD) is a benign fibrous lesion in the albuginea of the penis that can occur in men of various ages. Despite the fact that epidemiological and pathophysiological data on PD are contradictory, there are a number of comorbidities that suggest a genetic predisposition to this pathology. Genetic and molecular studies of PD are insufficient and their results are often contradictory. This literature review will consider the most studied and potential genetic predictors of PD, namely: transforming growth factor β1, myostatin, matrix metalloproteinases, Wnt signaling pathway, microRNAs (MiR-29b), major histocompatibility complex proteins (human leukocyte antigen). Expanding the possibilities of early diagnosis of the disease will increase the effectiveness of the treatment.