Diagnosis, management and prevention of Pediatric Acute Hemolytic Anemia: Egyptian adapted evidence-based clinical practice guidelines

IF 0.5 Q4 PEDIATRICS
Galila Mokhtar, Ashraf Abdel Baky, Ilham Youssry, Iman Ragab, Laila Sherief, Marwa Zakaria, Mervat Hesham, Nouran Salah, Rasha Abdel-Raouf, Sara Makkeyah, Sherein Shalaby, Sonia Adolf Habib, Tarek Omar, Yasser Amer, Niveen M. Salama
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引用次数: 0

Abstract

Abstract Background Acute hemolytic anemia (AHA) is a common emergency in pediatric emergency departments, hence the need to adapt pre-existing high-quality practice guidelines for the diagnosis, management, and prevention of AHA to be available for national use. Methods The guideline panel used the adapted ADAPTE methodology. The panel prioritized the health questions and recommendations according to their importance for clinicians and patients. The procedure included searching for existing guidelines, quality appraisal, and adaptation of the recommendations to be used in low-resource countries. Results The guideline provided approach to a child with AHA: laboratory diagnosis of glucose-6-phosphate dehydrogenase (G6PD) deficiency, autoimmune hemolytic anemia (AIHA), and hemolytic uremic syndrome (HUS); treatment of AHA including indications for red cell transfusion, medical treatment, plasma exchange, and indications of antibiotic in HUS; how to avoid further episodes of hemolysis; and when to refer to a hematologist. Implementation tools included a checklist for history and examination, lists of differential diagnoses, flow charts for the diagnosis of AHA, and a list of medications and food to be avoided in patients with G6PD deficiency. Conclusion This adapted guideline will aid decision-making related to the diagnosis, management, and prevention of AHA.
儿童急性溶血性贫血的诊断、管理和预防:埃及改编的循证临床实践指南
背景:急性溶血性贫血(AHA)是儿科急诊科常见的急症,因此需要对已有的高质量的AHA诊断、管理和预防实践指南进行调整,以供全国使用。方法指南组采用ADAPTE方法。该小组根据对临床医生和患者的重要性对健康问题和建议进行了优先排序。该程序包括查找现有准则、质量评价和修改建议,以便在资源不足的国家使用。结果:该指南为一名AHA患儿提供了治疗方法:实验室诊断为葡萄糖-6-磷酸脱氢酶(G6PD)缺乏症、自身免疫性溶血性贫血(AIHA)和溶血性尿毒症综合征(HUS);AHA的治疗包括红细胞输注、药物治疗、血浆置换和溶血性尿毒综合征的抗生素适应症;如何避免再次发生溶血;什么时候去找血液科医生。实施工具包括病史和检查清单、鉴别诊断清单、AHA诊断流程图以及G6PD缺乏症患者应避免的药物和食物清单。结论:本指南将有助于AHA的诊断、管理和预防决策。
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来源期刊
自引率
0.00%
发文量
32
审稿时长
9 weeks
期刊介绍: The Gazette is the official journal of the Egyptian Pediatric Association. The main purpose of the Gazette is to provide a place for the publication of high-quality papers documenting recent advances and new developments in both pediatrics and pediatric surgery in clinical and experimental settings. An equally important purpose of the Gazette is to publish local and regional issues related to children and child care. The Gazette welcomes original papers, review articles, case reports and short communications as well as short technical reports. Papers submitted to the Gazette are peer-reviewed by a large review board. The Gazette also offers CME quizzes, credits for which can be claimed from either the EPA website or the EPA headquarters. Fields of interest: all aspects of pediatrics, pediatric surgery, child health and child care. The Gazette complies with the Uniform Requirements for Manuscripts submitted to biomedical journals as recommended by the International Committee of Medical Journal Editors (ICMJE).
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