Correlation between Serum Troponin-I Levels and Acute Stroke in Coronary Artery Disease Patients

Abstract

Background: Studies reveal that the average age of stroke in less developed nations would be younger due to changing population structures brought on by increased mortality rates and other causes of death. The risk of death for AS patients is highest in the first few weeks and varies from 20 to 50% in the first month, depending on age, severity of stroke, other medical disorders, and treatment effectiveness for all outcomes. Furthermore, Tn subunits bind to muscle filaments, according to studies. Since it is a sensitive sign of myocardial necrosis, researchers have determined that it is widely used to diagnose acute coronary syndromes. Objective: To assess the link between serum TnI levels and AS in CAD cases. Methods: Based on the average patient volume and available resources at the KIMS, Karad from October 2017 to December 2019, our study comprised 57 patients. A structured and validated questionnaire was utilized to collect data. Microsoft Excel received the data. Tests were conducted using Epi-Info 7.2 and SPSS version 20. The student’s t-test is used to determine correlation, whereas the chi-square test was utilized to measure association. Result: A strong correlation was observed between mortality and elevated TnI levels in AS cases (p < 0.001). Conclusion: Patients with AIS showed significant TnI levels. Serum TnI levels were higher in patients with AIS, despite these levels being thought to be more selective for myocardial damage. TnI levels and AIS prognosis were substantially associated. The results of this study will improve our understanding of cardiac enzymes in AIS patients as well as how they impact prognosis.