Effect of Calorie Restriction on the Expression of Sirtuin1 as an Antiaging Biomarker

IF 0.8 Q3 MULTIDISCIPLINARY SCIENCES

Makara Journal of Science Pub Date : 2023-09-25 DOI:10.7454/mss.v27i3.1529

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Abstract

Calorie restriction (CR) is the most effective method for delaying aging and preventing the onset of age-related diseases. Sirtuins constitute a family of nicotinamide adenine dinucleotide (NAD)-dependent histone deacetylases. Their activity can be regulated by NAD+/NADH levels, which are influenced by nutrient intake, a variable acted upon by CR. This review elaborates on the link between CR and sirtuin1 (SIRT1). It retrieved articles from several sources, such as ClinicalKey, PubMed, and ScienceDirect. It discusses the up-to-date knowledge of how SIRT1 acts as a nutrient sensor and regulator of molecular mechanisms. These mechanisms include the control of the cell cycle, enhancing mitochondrial quality control, activating fatty acid oxidation, and stimulating anti-inflammatory effects. Disruptions in the aforementioned mechanisms are the basis of aging. CR increases the expression of SIRT1, which enhances the biogenesis and dynamics of mitochondria, resulting in an antiaging effect. In CR, SIRT1 is activated and stimulates different pathways, especially those related to mitochondrial activity and effectiveness, leading to an antiaging effect in collaboration with other antiaging biomarkers

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热量限制对抗衰老生物标志物Sirtuin1表达的影响

热量限制(CR)是延缓衰老和预防与年龄有关的疾病发病的最有效方法。Sirtuins构成了一个烟酰胺腺嘌呤二核苷酸(NAD)依赖性组蛋白去乙酰化酶家族。它们的活性可受NAD+/NADH水平的调控，而NAD+/NADH水平受营养摄入的影响，而营养摄入又受CR的影响。本文详细阐述了CR与SIRT1之间的联系。它从几个来源检索文章，如ClinicalKey、PubMed和ScienceDirect。它讨论了SIRT1如何作为营养传感器和分子机制调节器的最新知识。这些机制包括控制细胞周期、加强线粒体质量控制、激活脂肪酸氧化和刺激抗炎作用。上述机制的破坏是衰老的基础。CR增加SIRT1的表达，从而增强线粒体的生物发生和动力学，从而达到抗衰老的作用。在CR中，SIRT1被激活并刺激不同的通路，特别是与线粒体活性和有效性相关的通路，从而与其他抗衰老生物标志物协同发挥抗衰老作用

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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