Effects of Paracetamol on the Development of Zebrafish (Danio rerio)

IF 0.6 Q3 AGRICULTURE, MULTIDISCIPLINARY

Pertanika Journal of Tropical Agricultural Science Pub Date : 2023-10-31 DOI:10.47836/pjtas.46.4.06

Ajeng Istyorini Asmoning Dewanti, Tony Prince Kunjirika, Raden Roro Risang Ayu Dewayani Putri, Ascarti Adaninggar, Anita Restu Puji Raharjeng, Bambang Retnoaji, Ardaning Nuriliani, Fajar Sofyantoro, Nur Indah Septriani, Hendry T. S. S. G. Saragih

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引用次数: 0

Abstract

The misuse of paracetamol is becoming more prevalent worldwide. Due to non-compliance with recommended dosage and regulations, paracetamol consumption can result in serious health issues such as liver necrosis, kidney damage, heart damage, and hematological changes. This study sought to investigate the impact of paracetamol on the development of zebrafish embryos, which are often used as a model for assessing the effect of drug exposure on animals. The results indicated that paracetamol negatively affects the hatching and survival rates of zebrafish. Additionally, paracetamol exposure caused spinal abnormalities, pericardial edema, hypopigmentation, reduced heart rate, and spontaneous movement in zebrafish larvae. The developmental abnormalities in zebrafish were more significant with higher concentrations and longer exposure times. These findings may provide valuable insights into the detrimental impact of paracetamol on aquatic animals.

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扑热息痛对斑马鱼发育的影响

对乙酰氨基酚的滥用在世界范围内变得越来越普遍。由于不遵守推荐的剂量和规定，扑热息痛的消费可导致严重的健康问题，如肝坏死，肾损伤，心脏损伤和血液变化。本研究旨在研究扑热息痛对斑马鱼胚胎发育的影响，斑马鱼胚胎通常被用作评估药物暴露对动物影响的模型。结果表明，扑热息痛对斑马鱼的孵化率和存活率有负面影响。此外，扑热息痛暴露导致斑马鱼幼虫脊柱异常、心包水肿、色素减退、心率降低和自发运动。浓度越高、暴露时间越长，斑马鱼发育异常越明显。这些发现可能对扑热息痛对水生动物的有害影响提供有价值的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pertanika Journal of Tropical Agricultural Science Agricultural and Biological Sciences-Agronomy and Crop Science

CiteScore

1.10

自引率

16.70%

发文量