A catastrophic combination of Kikuchi–Fujimoto disease and systemic lupus erythematosus complicated with autoimmune hemolytic anemia in a pregnant woman

IF 0.2 Q4 MEDICINE, GENERAL & INTERNAL
RaghaviAbhilesh Bembey, Ram Babu, Ajay Tanwar, Manoj Sareen, Mansi Jain, Kush Goyal
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引用次数: 0

Abstract

Kikuchi–Fujimoto disease (KFD) or histiocytic necrotizing lymphadenitis is a benign, idiopathic, self-limiting, and systemic disorder involving lymph nodes (LNs) of unknown etiology. The first case was reported in Japan, with an increasing incidence globally. The disease is a challenge because of the nonspecific clinical features, and the disease is easily mistaken for other forms of lymphadenitis leading to misdiagnosis and mistreatment. It is associated with many autoimmune disorders, of which systemic lupus erythematosus (SLE) is the most common association. The diagnosis is based on the histological examination of LNs, which typically reveals necrosis surrounded by histiocytes with crescentic nucleus, immunoblasts and plasma cells, and absence of neutrophils. We report the case of a 24-year-old pregnant Indian female patient without any relevant past medical history to demonstrate the correlation between KFD and SLE complicated with autoimmune hemolytic anemia.
孕妇的菊池-藤本病和系统性红斑狼疮合并自身免疫性溶血性贫血的灾难性组合
Kikuchi-Fujimoto病(KFD)或组织细胞坏死性淋巴结炎是一种病因不明的良性,特发性,自限性和系统性疾病,涉及淋巴结(LNs)。日本报告了第一例病例,全球发病率不断上升。这种疾病是一个挑战,因为非特异性的临床特征,疾病很容易被误认为是其他形式的淋巴结炎,导致误诊和虐待。它与许多自身免疫性疾病有关,其中系统性红斑狼疮(SLE)是最常见的关联。诊断基于LNs的组织学检查,通常显示坏死被新月形核的组织细胞、免疫母细胞和浆细胞包围,中性粒细胞缺失。我们报告一例24岁的印度孕妇,无任何相关病史,以证明KFD与SLE合并自身免疫性溶血性贫血之间的相关性。
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来源期刊
Indian Journal of Medical Specialities
Indian Journal of Medical Specialities MEDICINE, GENERAL & INTERNAL-
自引率
16.70%
发文量
51
期刊介绍: The Indian Journal of Medical Specialities is an all-encompassing peer-reviewed quarterly journal. The journal publishes scholarly articles, reviews, case reports and original research papers from medical specialities specially pertaining to clinical patterns and epidemiological profile of diseases. An important highlight is the emphasis on undergraduate and postgraduate medical education including various aspects of scientific paper-writing. The journal gives priority to research originating from the developing world, including from the tropical regions of the world. The journal also publishes special issues on health topics of current interest. The Indian Journal of Medical Specialities is one of the very few quality multispeciality scientific medical journals.
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