Pulmonary involvement in primary Sjögren's syndrome (pSS): contribution of the different means in the systematic investigation

Maysam Jridi, Yosra Cherif, Samar Derbal, Fatma Ben Dahmen, Meya Abdallah
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Abstract

The prevalence of pulmonary involvement in primary Sjögren´s syndrome (pSS) varies depending on investigation methods. Our study aimed to identify the contribution of the different means of investigation in the systematic screening for pulmonary involvement in pSS. This is a retrospective and descriptive study including medical records of pSS patients, who validated the 2016 American College of Rheumatology/European League Against Rheumatism classification criteria for pSS and who had undergone pulmonary assessment. We enrolled 30 patients: twenty-nine females (97%) and one male (3%). The mean age was 55±17.4. In nine patients (30%), pulmonary disease revealed the diagnosis. Dyspnoea and cough were respectively reported by 43% (N=13) and 30% (N=9) of patients. The six-minute walk test showed desaturation in four cases (14%) and the percent predicted distance was less than 70% in three cases (11%). Pulmonary function tests (PFTs) showed restrictive patterns (N=7, 26%), obstructive patterns (N=2, 7%), combined patterns (N=1, 4%), and isolated small airway disease (N=1, 4%). The prevalence of pulmonary involvement based on high-resolution computed tomography (HRCT) was 31% (N=9/29). The most frequent interstitial lung disease (ILD) was observed in five scans (56%) and usual interstitial pneumonia was the most frequently seen in three cases (60%). Bronchiolitis was observed in four cases (25%) out of 16 abnormal scans. The six-minute walk test results correlated with PFT results (P<0.05). Pulmonary involvement was noted in 50% of cases (N=15). It was clinically silent in one-third of cases (N=5). In conclusion, pulmonary involvement in Sjögren´s syndrome can be asymptomatic in 33% of cases. The six-minute walk test has a strong correlation with the results of PFT, it should be considered as an assessment tool that reflects the functional state of the patient.
原发性Sjögren综合征(pSS)肺部受累:不同方法在系统调查中的贡献
原发性Sjögren综合征(pSS)肺部受累的患病率因调查方法而异。我们的研究旨在确定不同的调查方法对pSS肺部受累的系统筛查的贡献。这是一项回顾性和描述性研究,包括pSS患者的医疗记录,这些患者验证了2016年美国风湿病学会/欧洲抗风湿病联盟对pSS的分类标准,并接受了肺部评估。我们纳入了30例患者:29例女性(97%)和1例男性(3%)。平均年龄55±17.4岁。9例(30%)患者的诊断为肺部疾病。43% (N=13)的患者出现呼吸困难,30% (N=9)的患者出现咳嗽。6分钟步行测试显示,有4例(14%)患者的血饱和度下降,有3例(11%)患者的预测距离低于70%。肺功能试验(PFTs)显示限制性型(N= 7,26%)、阻塞性型(N= 2,7%)、合并型(N= 1,4%)和孤立性小气道疾病(N= 1,4%)。基于高分辨率计算机断层扫描(HRCT)的肺部受累患病率为31% (N=9/29)。最常见的间质性肺疾病(ILD)见于5例(56%),常见的间质性肺炎见于3例(60%)。16例异常扫描中有4例(25%)出现细支气管炎。6分钟步行试验结果与PFT结果相关(P<0.05)。50%的病例(N=15)发现肺部受累。三分之一的病例临床无症状(N=5)。总之,33%的Sjögren综合征患者无症状累及肺部。6分钟步行试验与PFT结果相关性强,可作为反映患者功能状态的评估工具。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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