Solubility of codeine phosphate in N -methyl-2-pyrrolidone + 1-propanol mixtures at different temperatures

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-11-03 DOI:10.1080/00319104.2023.2275316

Homa Rezaei, Elaheh Rahimpour, Fleming Martinez, Hongkun Zhao, Abolghasem Jouyban

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Abstract

ABSTRACTThe purpose of the current study is the investigation of the solubility data and thermodynamic properties of codeine phosphate in mixtures of N-methyl-2-pyrrolidone and 1-propanol under atmospheric pressure at 293.2–313.2 K. Positive correlations of the solubility with temperature and N-methyl-2-pyrrolidone ratio were observed. The measured data were correlated using some mathematical models, and their reliability was studied by computing the mean relative deviations of the back-calculated values. The density values of codeine phosphate saturated solutions were also measured and correlated using the Jouyban–Acree model. Furthermore, the apparent thermodynamic properties of the codeine phosphate solubilisation (e.g. standard enthalpy, entropy, and Gibbs free energy) are also computed based on Gibbs and van’t Hoff equations and reported.KEYWORDS: Codeine phosphatesolubilityN-methyl-2-pyrrolidone1-propanolbinary solvent mixturecosolvency models AcknowledgmentsThe research protocol was approved and supported by the Student Research Committee, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran, under grant number 67275.Disclosure statementNo potential conflict of interest was reported by the author(s).Additional informationFundingThe work was supported by the Student Research Committee, Tabriz University of Medical Sciences [67275].

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不同温度下磷酸可待因在N -甲基-2-吡咯烷酮+ 1-丙醇混合物中的溶解度

摘要本文研究了磷酸可待因在n -甲基-2-吡咯烷酮和1-丙醇混合物中在293.2 ~ 313.2 K常压下的溶解度和热力学性质。溶解度与温度和n -甲基-2-吡咯烷酮比呈正相关。利用数学模型对实测数据进行关联，并通过计算反算值的平均相对偏差来研究其可靠性。还测量了磷酸可待因饱和溶液的密度值，并使用Jouyban-Acree模型进行了关联。此外，还根据Gibbs和van 't Hoff方程计算了磷酸可待因溶解的表观热力学性质(如标准焓、熵和吉布斯自由能)。本研究方案由伊朗大不里士(Tabriz)医科大学药学院学生研究委员会批准并支持，批准号67275。披露声明作者未报告潜在的利益冲突。这项工作得到了大不里士医科大学学生研究委员会的支持[67275]。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.