Myoung Sun Kang, Thi Luyen Cao, Tae Heon Lee, Nathan Cho, Tae Gyu Yi, Nam il Park, Baul Ko, Ho Cheol Kim, Jong Hyang Bae, Yang Gyu Ku
{"title":"Comparison of Rutin Content, Anti-Cancer Activity, and Anti-Obesity Effect of Four Asparagus (Asparagus officinalis) Cultivars","authors":"Myoung Sun Kang, Thi Luyen Cao, Tae Heon Lee, Nathan Cho, Tae Gyu Yi, Nam il Park, Baul Ko, Ho Cheol Kim, Jong Hyang Bae, Yang Gyu Ku","doi":"10.7235/hort.20230043","DOIUrl":null,"url":null,"abstract":"This study aimed to compare rutin content, anti-cancer activity against Calu-6 lung, HCT-116 colorectal, and MCF-7 breast cancer cell lines and anti-obesity activity of Jersey Giant, Jersey Supreme, NJ953, and UC157 asparagus cultivars. The rutin content in the spears of the four cultivars gradually decreased from the tip to the basal segments. In the spear tip segments, the rutin content of the Jersey Giant and UC157 cultivars was higher than that in the Jersey Supreme and NJ953 cultivars; whereas the rutin content in the basal segments of Jersey Supreme and UC157 spears was higher than that of Jersey Giant and NJ953 cultivars. The rutin content in the whole spear of the UC157 cultivar was significantly higher than that in Jersey Giant and NJ953 spears. Asparagus spears exhibited anti-cancer activity against HCT-116 colorectal cancer cells more effectively than Calu-6 lung and MCF-7 breast cancer cells, as demonstrated by the lower viability of HCT-116 colorectal cancer cells compared to the viability of the other cancer cell lines. The Jersey Giant cultivar showed higher anti-cancer activity against Calu-6 lung cancer cell line at spear extract concentrations of 400 and 800 µg·mL-1. The UC157 cultivar showed higher anti-cancer activity against HCT-116 colorectal cancer cells at spear extract concentrations from 100 to 800 µg·mL-1 compared to Jersey Giant and Jersey Supreme cultivars. The rutin content was negatively correlated with the viability of HCT-116 colorectal and MCF-7 breast cancer cells, indicating that the high rutin content of the UC157 cultivar is linked to high anti-cancer activity against HCT-116 colorectal and MCF-7 breast cancer cells. The spear extracts from the four asparagus cultivars significantly decreased lipid accumulation. There were no significant differences in the effects to 3T3-L1 preadipocyte viability and lipid accumulation among the four cultivars. These results suggest the potential of the UC157 cultivar with its high rutin content and anti-cancer activity against HCT-116 colorectal cancer cells, also suggest that the consumption of asparagus may contribute to the alleviation of obesity.","PeriodicalId":17858,"journal":{"name":"Korean Journal of Horticultural Science & Technology","volume":null,"pages":null},"PeriodicalIF":1.0000,"publicationDate":"2023-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Korean Journal of Horticultural Science & Technology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.7235/hort.20230043","RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"HORTICULTURE","Score":null,"Total":0}
引用次数: 0
Abstract
This study aimed to compare rutin content, anti-cancer activity against Calu-6 lung, HCT-116 colorectal, and MCF-7 breast cancer cell lines and anti-obesity activity of Jersey Giant, Jersey Supreme, NJ953, and UC157 asparagus cultivars. The rutin content in the spears of the four cultivars gradually decreased from the tip to the basal segments. In the spear tip segments, the rutin content of the Jersey Giant and UC157 cultivars was higher than that in the Jersey Supreme and NJ953 cultivars; whereas the rutin content in the basal segments of Jersey Supreme and UC157 spears was higher than that of Jersey Giant and NJ953 cultivars. The rutin content in the whole spear of the UC157 cultivar was significantly higher than that in Jersey Giant and NJ953 spears. Asparagus spears exhibited anti-cancer activity against HCT-116 colorectal cancer cells more effectively than Calu-6 lung and MCF-7 breast cancer cells, as demonstrated by the lower viability of HCT-116 colorectal cancer cells compared to the viability of the other cancer cell lines. The Jersey Giant cultivar showed higher anti-cancer activity against Calu-6 lung cancer cell line at spear extract concentrations of 400 and 800 µg·mL-1. The UC157 cultivar showed higher anti-cancer activity against HCT-116 colorectal cancer cells at spear extract concentrations from 100 to 800 µg·mL-1 compared to Jersey Giant and Jersey Supreme cultivars. The rutin content was negatively correlated with the viability of HCT-116 colorectal and MCF-7 breast cancer cells, indicating that the high rutin content of the UC157 cultivar is linked to high anti-cancer activity against HCT-116 colorectal and MCF-7 breast cancer cells. The spear extracts from the four asparagus cultivars significantly decreased lipid accumulation. There were no significant differences in the effects to 3T3-L1 preadipocyte viability and lipid accumulation among the four cultivars. These results suggest the potential of the UC157 cultivar with its high rutin content and anti-cancer activity against HCT-116 colorectal cancer cells, also suggest that the consumption of asparagus may contribute to the alleviation of obesity.
期刊介绍:
Horticultural Science and Technology (abbr. Hortic. Sci. Technol., herein ‘HST’; ISSN, 1226-8763), one of the two official journals of the Korean Society for Horticultural Science (KSHS), was launched in 1998 to provides scientific and professional publication on technology and sciences of horticultural area. As an international journal, HST is published in English and Korean, bimonthly on the last day of even number months, and indexed in ‘SCIE’, ‘SCOPUS’ and ‘CABI’. The HST is devoted for the publication of technical and academic papers and review articles on such arears as cultivation physiology, protected horticulture, postharvest technology, genetics and breeding, tissue culture and biotechnology, and other related to vegetables, fruit, ornamental, and herbal plants.