Comparison of Rutin Content, Anti-Cancer Activity, and Anti-Obesity Effect of Four Asparagus (Asparagus officinalis) Cultivars

IF 1 4区 农林科学 Q3 HORTICULTURE
Myoung Sun Kang, Thi Luyen Cao, Tae Heon Lee, Nathan Cho, Tae Gyu Yi, Nam il Park, Baul Ko, Ho Cheol Kim, Jong Hyang Bae, Yang Gyu Ku
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引用次数: 0

Abstract

This study aimed to compare rutin content, anti-cancer activity against Calu-6 lung, HCT-116 colorectal, and MCF-7 breast cancer cell lines and anti-obesity activity of Jersey Giant, Jersey Supreme, NJ953, and UC157 asparagus cultivars. The rutin content in the spears of the four cultivars gradually decreased from the tip to the basal segments. In the spear tip segments, the rutin content of the Jersey Giant and UC157 cultivars was higher than that in the Jersey Supreme and NJ953 cultivars; whereas the rutin content in the basal segments of Jersey Supreme and UC157 spears was higher than that of Jersey Giant and NJ953 cultivars. The rutin content in the whole spear of the UC157 cultivar was significantly higher than that in Jersey Giant and NJ953 spears. Asparagus spears exhibited anti-cancer activity against HCT-116 colorectal cancer cells more effectively than Calu-6 lung and MCF-7 breast cancer cells, as demonstrated by the lower viability of HCT-116 colorectal cancer cells compared to the viability of the other cancer cell lines. The Jersey Giant cultivar showed higher anti-cancer activity against Calu-6 lung cancer cell line at spear extract concentrations of 400 and 800 µg·mL-1. The UC157 cultivar showed higher anti-cancer activity against HCT-116 colorectal cancer cells at spear extract concentrations from 100 to 800 µg·mL-1 compared to Jersey Giant and Jersey Supreme cultivars. The rutin content was negatively correlated with the viability of HCT-116 colorectal and MCF-7 breast cancer cells, indicating that the high rutin content of the UC157 cultivar is linked to high anti-cancer activity against HCT-116 colorectal and MCF-7 breast cancer cells. The spear extracts from the four asparagus cultivars significantly decreased lipid accumulation. There were no significant differences in the effects to 3T3-L1 preadipocyte viability and lipid accumulation among the four cultivars. These results suggest the potential of the UC157 cultivar with its high rutin content and anti-cancer activity against HCT-116 colorectal cancer cells, also suggest that the consumption of asparagus may contribute to the alleviation of obesity.
四种芦笋品种芦丁含量、抗癌活性及抗肥胖作用的比较
本研究旨在比较Jersey Giant、Jersey Supreme、NJ953和UC157芦笋品种芦丁含量、对Calu-6肺癌、HCT-116结直肠癌和MCF-7乳腺癌细胞系的抗癌活性以及抗肥胖活性。4个品种的矛中芦丁含量从矛尖到矛基段逐渐降低。泽西巨和UC157品种的叶尖段芦丁含量高于泽西至尊和NJ953品种;而泽西至尊和UC157品种的茎基段芦丁含量高于泽西巨和NJ953品种。UC157品种全枪中芦丁含量显著高于泽西巨人和NJ953。芦笋矛对HCT-116结直肠癌细胞的抗癌活性比Calu-6肺癌细胞和MCF-7乳腺癌细胞更有效,这证明了HCT-116结直肠癌细胞的活性低于其他癌细胞系的活性。在400和800µg·mL-1的矛提取物浓度下,泽西巨人品种对Calu-6肺癌细胞系具有较高的抗癌活性。在100 ~ 800µg·mL-1的浓度范围内,UC157品种对HCT-116结直肠癌细胞的抗癌活性高于Jersey Giant和Jersey Supreme品种。芦丁含量与HCT-116结直肠癌和MCF-7乳腺癌细胞活力呈负相关,表明UC157品种芦丁含量高与抗HCT-116结直肠癌和MCF-7乳腺癌细胞活性高有关。四种芦笋品种的矛提取物显著降低了脂质积累。4个品种对3T3-L1前脂肪细胞活力和脂质积累的影响无显著差异。这些结果表明,UC157品种具有高芦丁含量和对HCT-116结直肠癌细胞的抗癌活性的潜力,也表明食用芦笋可能有助于减轻肥胖。
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来源期刊
CiteScore
2.00
自引率
0.00%
发文量
0
审稿时长
1 months
期刊介绍: Horticultural Science and Technology (abbr. Hortic. Sci. Technol., herein ‘HST’; ISSN, 1226-8763), one of the two official journals of the Korean Society for Horticultural Science (KSHS), was launched in 1998 to provides scientific and professional publication on technology and sciences of horticultural area. As an international journal, HST is published in English and Korean, bimonthly on the last day of even number months, and indexed in ‘SCIE’, ‘SCOPUS’ and ‘CABI’. The HST is devoted for the publication of technical and academic papers and review articles on such arears as cultivation physiology, protected horticulture, postharvest technology, genetics and breeding, tissue culture and biotechnology, and other related to vegetables, fruit, ornamental, and herbal plants.
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